Time Restricted Eating for WeIght LoSs MainTenance-2

The TWIST 2.0 study tests whether time-restricted eating (TRE) — limiting all food intake to a 10-hour window each day — helps adults maintain weight they have already lost, compared to eating without time restrictions. Weight regain after loss is a major challenge, and TRE may help by aligning eating with the body's natural circadian rhythms. Eligible participants are adults aged 25–65 who have lost at least 5% of their body weight non-surgically in the past 3 months, have a current BMI of 20.5–45 kg/m², own a smartphone, and do not have type 1 or 2 diabetes, an eating disorder, or currently follow intermittent fasting. Participation involves a 4-week run-in period, then 12 months of either following a 10-hour eating window with app-based food logging and behavioral coaching, or eating on their usual schedule, with body weight and composition measured at baseline, 6 months, and 12 months. This summary was prepared using AI to help patients understand the study in plain language.