Sacubitril/Valsartan in Patients With Prosthetic Heart Valves With Heart Failure and Reduced Ejection Fraction

This trial is studying whether sacubitril/valsartan (a combination heart failure drug) is safe and helpful for people who have an artificial heart valve and also have heart failure with a weakened heart pump. **You may be eligible if...** - You are 18 years of age or older - You have a prosthetic (artificial) heart valve - You have been diagnosed with heart failure with reduced ejection fraction — meaning your heart pumps less than 40% of its blood out with each beat - Your heart failure symptoms fall within NYHA class II–IV (ranging from mild symptoms during activity to symptoms at rest) **You may NOT be eligible if...** - Your blood pressure is unstable or too low (below 100/60 mmHg) - You have severe kidney impairment (eGFR below 30 mL/min) or severe liver disease - Your potassium level is too high (above 5.3 mmol/L) - You have severe pulmonary hypertension, dangerous heart rhythm problems, or a malignant tumor - You have a history of hereditary angioedema or prior serious reactions to study drugs Talk to your doctor to see if this trial is right for you.