RecruitingPhase 3NCT07195149

Comparing High and lOw-dose asPirin With Dual anTIplatelet Therapy for Three Months Using prasUgrel and aSpirin Following Coronary Artery Bypass Grafting. (OPTIMUS-CABG Trial)

Sponsor

Dolnośląskie Centrum Chorób Serca im.prof. Zbigniewa Religi MEDINET Sp. z o.o.

Enrollment

1,703 participants

Start Date

Nov 25, 2025

Study Type

INTERVENTIONAL

Conditions

Chronic Coronary Syndrome Stable Coronary Artery Disease CAD

Summary

The purpose of this study is to compare the effect of prasugrel plus low-dose aspirin versus high dose aspirin alone (300mg) and versus low dose aspirin alone (75 mg) in patients with chronic coronary disease undergoing coronary artery bypass grafting.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called DAPT (Low-Dose Aspirin 75 mg + Prasugrel 10 mg), a drug called High-Dose Aspirin 300 mg, and others for people with chronic coronary syndrome and stable coronary artery disease cad. The study is currently recruiting participants at 18 locations. People eligible for this study include aged 18 Years and older.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGHigh-Dose Aspirin 300 mg

High-dose Aspirin 300 mg once daily taken orally for three months

DRUGDAPT (Low-Dose Aspirin 75 mg + Prasugrel 10 mg)

Drug: Prasugrel 10 mg Prasugrel 10 mg once daily taken orally for 3 months Drug: Low-Dose Aspirin 75 mg once daily taken orally

DRUGLow-Dose Aspirin 75 mg

Low-Dose Aspirin 75 mg once daily taken orally

Locations(18)

University Clinical Hospital in Bialystok

Bialystok, Poland

Nicolaus Copernicus University Ludwik Rydygier Collegium Medicum in Bydgoszcz

Bydgoszcz, Poland

Medical University of Gdansk

Gdansk, Poland

Regional Specialist Hospital in Grudziadz

Grudziądz, Poland

Upper-Silesian Heart Center

Katowice, Poland

John Paul II Hospital

Krakow, Poland

Medical University of Lodz

Lodz, Poland

Zbigniew Religa Heart Center "Medinet"

Nowa Sól, Poland

Provincial Specialist Hospital in Olsztyn

Olsztyn, Poland

Institute of Medical Sciences in Opole

Opole, Poland

J. Struś Hospital

Poznan, Poland

Poznan University of Medical Sciences

Poznan, Poland

Pomeranian Medical University

Szczecin, Poland

Central Clinical Hospital of the Ministry of Interior and Administration

Warsaw, Poland

Medicover Hospital

Warsaw, Poland

Wroclaw Medical University

Wroclaw, Poland

Zbigniew Religa Heart Center "Medinet"

Wroclaw, Poland

Silesian Centre for Heart Diseases in Zabrze

Zabrze, Poland

View Full Details on ClinicalTrials.gov

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NCT07195149

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