Artificial Intelligence-Driven Medipixel Fractional Flow Reserve Versus Invasive Fractional Flow Reserve-Guided PCI Trial (AIM-FFR Trial)
Artificial Intelligence-Driven Angiography-Based Fractional Flow Reserve Versus Invasive Fractional Flow Reserve-Guided PCI
Samsung Medical Center
2,100 participants
Mar 18, 2026
INTERVENTIONAL
Conditions
Summary
The AIM-FFR trial is a prospective, multi-center, open-label, randomized controlled, non-inferiority trial. The current trial will evaluate non-inferiority of MPFFR-guided PCI, compared with invasive FFR-guided PCI in patients with coronary artery disease.
Eligibility
Inclusion Criteria5
- Subject must be at least 19 years of age
- Eligible for coronary angiography and/or percutaneous coronary intervention.
- Chronic coronary syndrome or acute coronary syndrome (non-culprit vessels only)
- Coronary artery disease in one or more native major epicardial vessels or their branches with reference vessel diameter of at least 2.5mm and with visually assessed coronary stenosis in which the physiological severity of the lesion is questionable (typically 40-90% diameter stenosis).
- Subject who is able to understand risks, benefits and treatment alternatives and sign informed consent voluntarily.
Exclusion Criteria14
- Patients unable to provide informed consent
- Patients with known intolerance to aspirin, P2Y12 inhibitors, or components of drug-eluting stents and drug-coated balloons
- Patients with coronary artery bypass grafting
- Patients who have non-cardiac co-morbid conditions with life expectancy <1 year
- Patients with cardiogenic shock or cardiac arrest
- Patients with severe left ventricular systolic dysfunction (ejection fraction <30%)
- Patients with severe valvular heart disease requiring open heart surgery
- Pregnant or lactating women
- Culprit vessel of patients with ST-elevation myocardial infarction (target lesions in non-culprit vessel can be enrolled)
- Chronic total occlusion (target lesions in vessels without chronic total occlusion can be enrolled)
- Ostial stenosis in left man coronary artery or right coronary artery
- Severe tortuosity of any target vessel
- Severe overlap in the stenosed segment
- Poor image quality precluding identification of vessel contours
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Interventions
Functionally significant stenosis will be defined as MPFFR≤0.80 or FFR≤0.80. For lesions with MPFFR≤0.80 or FFR≤0.80, PCI will be recommended under current guidelines, however, final decision regarding PCI will be at the discretion of operators. In the MPFFR-guided PCI group, on-site MPFFR value will be used in decision making of revascularization. If PCI is not performed for lesions with MPFFR≤0.80 or FFR≤0.80, the specific reasons will be collected in electronic case report form. For lesions with MPFFR\>0.80 or FFR\>0.80, PCI will be deferred.
Locations(23)
View Full Details on ClinicalTrials.gov
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NCT07329699