RecruitingNot ApplicableNCT07196371

Feasibility of Aerobic Exercise With Blood Flow Restriction Training in People Living With Type 2 Diabetes

Testing the Feasibility of Blood Flow Restriction Training to Enhance the Health Benefits of Exercise in Individuals With Type 2 Diabetes: a Pilot Randomized Controlled Trial

Sponsor

University of New Brunswick

Enrollment

60 participants

Start Date

Jan 1, 2026

Study Type

INTERVENTIONAL

Conditions

Type 2 Diabetes

Summary

The goal of this trial is to learn if blood flow restriction training with treadmill walking is possible for individuals living with type 2 diabetes. It will also learn about how the blood flow restriction with treadmill walking could improve health. The main questions it aims to answer are: Is 6 weeks of treadmill walking with blood flow restriction reasonable for people with type 2 diabetes to perform? Does treadmill walking with blood flow restriction training help manage type 2 diabetes better than just treadmill walking? Researchers will compare treadmill walking with blood flow restriction to treadmill walking without blood flow restriction to see if blood flow restriction works to manage type 2 diabetes based on fitness and blood sugar levels. Participants will: Perform treadmill walking with or without blood flow restriction for 96 minutes a week for 6 weeks. Visit the lab before and after the exercise for tests and questionnaires.

Eligibility

Min Age: 19 YearsMax Age: 64 Years

Plain Language Summary

Simplified for easier understanding

This trial is testing whether aerobic exercise combined with blood flow restriction training (BFR) — a technique using a cuff to partially reduce blood flow to the muscles during low-intensity exercise — is safe and feasible for people living with Type 2 diabetes. **You may be eligible if...** - You have been diagnosed with Type 2 diabetes and your HbA1c is between 5.7% and 9.0% - You are not currently regularly physically active (less than 150 minutes of moderate to vigorous activity per week) **You may NOT be eligible if...** - You have musculoskeletal problems that would prevent you from exercising - Your medications have changed in the past 3 months - You have peripheral vascular disease (a contraindication to blood flow restriction) - You have been diagnosed with low iron, anemia, sickle cell anemia, or other conditions that affect red blood cells - You have cardiovascular disease that would make exercising unsafe - You are on medications that would interfere with heart rate monitoring during exercise Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BEHAVIORALAerobic Training with Blood Flow Restriction

Participants will undergo a 6-week aerobic training intervention with blood flow restriction applied to the lower limbs. Blood flow restriction will be applied using a blood pressure cuff set between 60-80% of limb arterial occlusion pressure. Training will consist of treadmill walking at 40-50% of heart rate reserve (HRR) for 32 minutes per session, 3 times per week for a total of 96 minutes per week.

BEHAVIORALStandard Aerobic Training

Participants will follow the same aerobic training protocol as the AT+BFR group but without blood flow restriction. Training will consist of treadmill walking at 40-50% of HRR for 32 minutes per session, 3 times per week for a total of 96 minutes per week.