Randomized, Double-blind Crossover Trial Comparing Low-GI Functional vs. Standard Wholegrain Carbohydrates on Glycolipid Metabolism and Vascular Stress Markers in Adults With Suboptimal Triglyceridemia
Randomized, Double-Blind, Placebo-Controlled Crossover Clinical Trial to Evaluate the Effect of a Functional Low-Glycemic Index Carbohydrates Versus Standard Wholegrain Carbohydrates on Glycolipid Metabolism and Vascular Stress Markers in Subjects With Suboptimal Triglyceridemia
University of Bologna
40 participants
Feb 2, 2026
INTERVENTIONAL
Conditions
Summary
Low-glycemic index (GI) carbohydrates help prevent type 2 diabetes and cardiovascular disease by reducing postprandial glucose, insulin spikes, inflammation, and triglyceride synthesis. They improve weight, lipid profiles, and vascular health. Our study will compare functional low-GI vs. standard wholegrain carbs in a Mediterranean diet to assess their effect on the Triglycerides-Glucose Index, a marker of metabolic and cardiovascular risk, in subjects with suboptimal triglyceride levels.
Eligibility
Inclusion Criteria4
- Male or female aged ≥ 18 years
- TG>150 mg/dL
- Subjects who have the capability to communicate and to comply with the study's requirements.
- Subjects agree to participate in the study and having dated and signed the informed consent form.
Exclusion Criteria4
- Gluten hypersensitivity/Coeliac disease diagnosis
- BMI>30 kg/m2
- Any preventive treatments (i.e. lipid-lowering drugs, antihypertensives) not stabilized in type and dose for at least 3 months
- Any medical or surgical condition that would limit the patient adhesion to the study protocol.
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Interventions
Altograno® Pasta, Pizza and Flatbrad, in substitution of the same amount of carbohydrates usually eaten in a stabilized diet
Industrial standard whole-grain Pasta, Pizza and Flatbrad, in substitution of the same amount of carbohydrates usually eaten in a stabilized diet
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT07198789