RecruitingNCT07217054

Colonic Tissue Biopsy Detection of Phosphorylated Alpha-synuclein for Parkinson's Diagnosis or REM Sleep Behavior Disorder

Detection of Phosphorylated Alpha-Synuclein in Colonic Tissue Biopsy During Routine Colonoscopy

Sponsor

CND Life Sciences

Enrollment

40 participants

Start Date

Nov 4, 2025

Study Type

OBSERVATIONAL

Conditions

Parkinson Disease Parkinson PARKINSON DISEASE (Disorder)Parkinson's Disease

Summary

The goal of this observational study is to learn whether tissue samples taken from the colon during routine colonoscopy can detect signs of Parkinson's disease or REM Sleep Behavior Disorder (RBD). The main question it aims to answer is: Can doctors find a protein called alpha-synuclein in colon tissue samples from people with Parkinson's disease and RBD? Currently, Parkinson's disease is diagnosed by observing symptoms like tremors and movement problems and RBD by loss of muscle atonia during REM sleep, but by then the disease has already progressed significantly. Earlier detection could help doctors start treatment sooner.

Eligibility

Min Age: 40 YearsMax Age: 99 Years

Inclusion Criteria5

Relatively healthy men and women ≥40-99 years of age
Patients with a diagnosis of
Clinically confirmed PD or
Clinically confirmed RBD with no diagnosis of PD, DLB or MSA
Patients must have agreed to undergo a routine colonoscopy as part of their screening or surveillance for colon cancer or for diagnostic purposes for the exclusion of other GI diseases

Exclusion Criteria6

Use of anticoagulants (Plavix or aspirin alone is allowed)
Under active treatment for colon cancer; 30-day post anti-cancer treatment allowed
Current, ongoing gastrointestinal illness
Recent intrabdominal surgery
Pregnant or planning to become pregnant before the scheduled colonoscopy
Significant cognitive impairment, as determined by study investigators