RecruitingNot ApplicableNCT07221201

Integrating Project YES! With WHO-Endorsed Mental Health Approaches Among Youth Living With HIV

Reducing the Intersecting Stigmas of HIV, Violence Victimization, and Mental Health: a Randomized Controlled Pilot Integrating Project YES! Youth Engaging for Success With WHO-Endorsed Mental Health Approaches Among Youth Living With HIV in Ndola, Zambia

Sponsor

Johns Hopkins Bloomberg School of Public Health

Enrollment

400 participants

Start Date

Oct 25, 2025

Study Type

INTERVENTIONAL

Conditions

Anxiety HIV (Human Immunodeficiency Virus)Mental Health Depression in Adolescence Stigma

Summary

The proposed study will address the intersecting stigmas of HIV, violence and depression among adolescents and young adults (15-24) living with HIV (AYALHIV) in Zambia. The study will integrate a WHO-endorsed mental health approach into an existing HIV-stigma-reducing intervention, and refine measures of internalized and intersecting stigmas, to create and test the feasibility of Project YES+- a combined youth peer mentoring and lay mental health intervention. This research aims to shift HIV care and treatment for AYALHIV by addressing the multiple internalized and intersecting stigmas that impeded antiretroviral adherence and HIV viral suppression.

Eligibility

Min Age: 15 Years

Plain Language Summary

Simplified for easier understanding

This study, based in Zambia, is testing a program called Project YES! that combines mental health support with HIV care for young people living with HIV. It aims to improve mental well-being and help youth stay on their HIV treatment. **You may be eligible if...** - You are between 15 and 21 years old - You are living with HIV and have been on your current HIV medication for at least 6 months - You speak Bemba (the local language) - You live within 30 minutes of the study clinic - You are available to attend sessions over 4-8 months - Caregivers: You are 25 or older, caring for an eligible young person, and meet the same language and location requirements **You may NOT be eligible if...** - Another person from your household is already enrolled - You are at imminent risk of suicide - You are not on first-line HIV treatment Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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