Integrating Project YES! With WHO-Endorsed Mental Health Approaches Among Youth Living With HIV
Reducing the Intersecting Stigmas of HIV, Violence Victimization, and Mental Health: a Randomized Controlled Pilot Integrating Project YES! Youth Engaging for Success With WHO-Endorsed Mental Health Approaches Among Youth Living With HIV in Ndola, Zambia
Johns Hopkins Bloomberg School of Public Health
400 participants
Oct 25, 2025
INTERVENTIONAL
Conditions
Summary
The proposed study will address the intersecting stigmas of HIV, violence and depression among adolescents and young adults (15-24) living with HIV (AYALHIV) in Zambia. The study will integrate a WHO-endorsed mental health approach into an existing HIV-stigma-reducing intervention, and refine measures of internalized and intersecting stigmas, to create and test the feasibility of Project YES+- a combined youth peer mentoring and lay mental health intervention. This research aims to shift HIV care and treatment for AYALHIV by addressing the multiple internalized and intersecting stigmas that impeded antiretroviral adherence and HIV viral suppression.
Eligibility
Inclusion Criteria12
- For youth
- Be between ages 15-21
- living within 30-minutes, by personal transportation, of the clinic by self-report,
- and being available to attend sessions and data collection over a 4-8 month time period On ART for at least 6 months
- On first-line ART
- Speaks Bemba
- For caregivers
- Being 25 years of age or older
- Caring for an AYALHIV who meets the study eligibility criteria
- Speaks Bemba
- Living within 30-minutes, by personal transportation, of the clinic by self-report
- Being available to attend sessions and data collection over a 4-8 month time period
Exclusion Criteria3
- For youth,
- only one youth per household may join.
- Also participants will be excluded from joining the RCT if they are at imminent risk of suicide based on WHO guidance on the Self Help plus program.
Interventions
Project YES+ integrates Project YES!
Locations(1)
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NCT07221201