Mental Health Clinical Trials

174 recruitingLast updated: May 4, 2026

Mental Health Trials at a Glance

275 actively recruiting trials for mental health are listed on ClinicalTrialsFinder across 6 cities in 42 countries. The largest study group is Not Applicable with 186 trials, with the heaviest enrollment activity in New York, Chicago, and New Haven. Lead sponsors running mental health studies include Yale University, Chinese University of Hong Kong, and Colorado State University.

Browse mental health trials by phase

Treatments under study

About Mental Health Clinical Trials

Looking for clinical trials for Mental Health? There are currently 174 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Mental Health trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Mental Health clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 275 trials

Recruiting
Not Applicable

ACT Group for Family Caregivers of Stroke Survivors

Caregiver BurdenCaregiver StressCaregiver Burnout+11 more
The Wright Institute30 enrolled1 locationNCT07528261
Recruiting
Phase 2

Parenting in 2 Worlds Multisite Trial

Substance UseParentingMental Health Wellness 1+1 more
Arizona State University1,440 enrolled4 locationsNCT06324318
Recruiting
Not Applicable

SBIR/ STTR Family Check-up Online

Academic AchievementMental HealthParenting Stress
University of Oregon1,270 enrolled1 locationNCT06876246
Recruiting

Women s Health Awareness Community Resiliency, Environmental Action and Collaborations for Health (REACH) Equity

Mental Health
National Institute of Environmental Health Sciences (NIEHS)700 enrolled1 locationNCT04983251
Recruiting
Not Applicable

Effect of Sun Tai Chi on the Cardiopulmonary System and Mental Health in University Students

University StudentsMental Health Conditions
Universidad Católica del Maule56 enrolled1 locationNCT07044154
Recruiting
Not Applicable

Just-in-Time Training for Youth Mentors

DepressionMental Health IssueAnxiety
University of Minnesota204 enrolled1 locationNCT07129070
Recruiting

BEYOND Study: Improving HIV Treatment and Well-Being Among Young MSM in Vietnam

HIV InfectionsMental HealthMedication Adherence
Center for Applied Research on Men and Community Health, Vietnam300 enrolled1 locationNCT07559266
Recruiting
Not Applicable

Virtual Patient Groups for Sarcoidosis Associated Fatigue

DepressionFatigueAnxiety+2 more
The Cleveland Clinic100 enrolled1 locationNCT07073963
Recruiting
Not Applicable

BASIS Optimization

Mental HealthEvidence Based Programs in SchoolsHealth Services
University of Washington32 enrolled1 locationNCT06672835
Recruiting
Not Applicable

Boosting Refugee Integration Through Psychological Intervention

Psychological DistressTraumaPTSD+1 more
University of Zurich1,200 enrolled1 locationNCT06776523
Recruiting
Not Applicable

Social Prescribing Intervention for Health Promotion in Community-Dwelling Older Adults

Health PromotionAgingMental Health
National Health Research Institutes, Taiwan1,500 enrolled1 locationNCT07540117
Recruiting
Not Applicable

Stress Phenotypes and Preterm Birth

StressMental Health IssueInflammation+1 more
Columbia University200 enrolled1 locationNCT05229666
Recruiting
Not Applicable

J-RISE: Relevant Implementation Strategies to Eliminate the Social and Structural Barriers to HIV Services Among Justice-involved Black Men Who Have Sex With Men and Other Key Populations

Mental HealthHIVSubstance Use+3 more
University of Chicago350 enrolled1 locationNCT06477588
Recruiting
Not Applicable

Doula Model of Care

Mental HealthMorbidityPerinatal
University of Pennsylvania230 enrolled1 locationNCT06915259
Recruiting
Not Applicable

Promoting Mental Health of Teachers and Caregiver Using a Personalized mHealth Toolkit in Uganda

Depression, AnxietyMental Health Literacy
NYU Langone Health1,180 enrolled2 locationsNCT06087159
Recruiting
Not Applicable

Developing and Testing a Digital Health Tool for INterseCtional Stigma Assessment and Reduction at Multiple Levels and mUltiple DimEnsions (INCLUDE) to Improve HIV Care in ART Centers in Nepal

Mental Health ConditionsHIV Antiretroviral Therapy (ART) AdherenceStigma+5 more
Possible88 enrolled1 locationNCT07370298
Recruiting
Not Applicable

Collaborative Care Model for Perinatal Wellness Support Services - Population-Level Equity-Centered Systems Change

Perinatal Mental Health
Women and Infants Hospital of Rhode Island14,820 enrolled1 locationNCT06849869
Recruiting
Not Applicable

Family Spirit Strengths

Mental Health IssueDepressive SymptomsAnxiety Disorders and Symptoms+1 more
Johns Hopkins Bloomberg School of Public Health188 enrolled3 locationsNCT05836090
Recruiting
Not Applicable

The New Beginnings Podcast: Brief Audio Intervention for Parents From Divorced and Separated Families

Child Mental HealthParent Child RelationshipParenting Intervention+5 more
Charla Aubrey Rhodes80 enrolled1 locationNCT07529548
Recruiting
Not Applicable

Intensive Case Management Between VA and Community Care for Suicide Prevention

Mental Health IssueSuicidal IdeationSocial Determinants of Health
VA Eastern Colorado Health Care System100 enrolled1 locationNCT07534358