RecruitingPhase 2Phase 3NCT07223242

Tailored Exercise Training Study Among Adults With HFpEF


Sponsor

University of Texas Southwestern Medical Center

Enrollment

120 participants

Start Date

Feb 18, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

Heart failure with preserved ejection fraction (HFpEF) is associated with a high morbidity and mortality burden. There are limited pharmacological options available for the treatment of HFpEF. Exercise intolerance (EI) is the cardinal symptom of HFpEF, which manifests as dyspnea and fatigue. EI leads to functional deconditioning and reduced quality of life (QOL), both of which elevate risk of death and hospitalization in patients with HFpEF. Supervised exercised training is associated with improvements in exercise capacity and QOL in adults with HFpEF. However, supervised exercise has not been widely utilized for the treatment of HFpEF due to logistical and fiscal barriers. This study will investigate the effects of a remote exercise training intervention on exercise capacity and skeletal muscle composition in patients with HFpEF, or those at risk for it. In addition, it will compare four different lifestyle interventions for their effects on exercise capacity.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is looking at whether a personalized exercise training program can help adults with heart failure with preserved ejection fraction (HFpEF) — a type of heart failure where the heart pumps normally but is too stiff to fill properly. Participants will use a mobile app to track their progress and adjust their exercise plan. **You may be eligible if...** - You are 18 years or older - You have been diagnosed with HFpEF, or you have several risk factors for it (such as diabetes, high blood pressure, obesity, or physical inactivity) - Your heart's pumping function (ejection fraction) is 50% or above - You have limitations in physical function or lower-than-expected fitness based on testing - You have a BMI of 28 or above (for the main study phase) - You are able to use a smartphone and a mobile app **You may NOT be eligible if...** - You were hospitalized in the past month - You have a history of frequent falls - Your kidney function is severely reduced (eGFR below 20) - You are pregnant - You are unable to exercise or cannot complete a fitness test - You have severe heart valve disease or end-stage lung disease requiring continuous oxygen Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BEHAVIORALModerate-intensity continuous training (MCT)

Tailored moderate-intensity exercise training video with weekly virtual meetings with a coach

BEHAVIORALResistance training

Resistance training videos assigned to patient

DRUGWeight loss

Initiation/intensification of weight loss medications, such as semaglutide or tirzepatide


Locations(1)

University of Texas Southwestern Medical Center

Dallas, Texas, United States

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NCT07223242


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