RecruitingPhase 2NCT07225777

Sex Differences in Neurobehavioral Response to THC

Sex Differences in Neurobehavioral Response to Acute THC in Adults With Cannabis Use Disorder

Sponsor

Medical University of South Carolina

Enrollment

40 participants

Start Date

Apr 27, 2026

Study Type

INTERVENTIONAL

Conditions

Cannabis Use Disorder

Summary

This study investigates sex differences in reward processing following acute THC administration in adults with cannabis use disorder (CUD). Using multimodal neuroimaging (MRS and fMRI), the study will assess glutamate levels in the nucleus accumbens and striatal BOLD response to monetary reward anticipation. Participants will complete two counterbalanced dosing sessions (oral THC 40 mg vs. placebo).

Eligibility

Min Age: 21 YearsMax Age: 45 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called Dronabinol and a drug called Placebo for people with cannabis use disorder. The study is currently recruiting participants at 1 location. People eligible for this study include aged 21 Years to 45 Years.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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