RecruitingNot ApplicableNCT07226284

Effects of Vagal Nerve Stimulation on Leg Muscle Activity and Posture in Parkinson's Disease

The Effects of Vagus Nerve Stimulation on Intrinsic Lower Leg Spinal Motoneuron Excitability in Parkinson's Disease.


Sponsor

University of Minnesota

Enrollment

75 participants

Start Date

Feb 10, 2026

Study Type

INTERVENTIONAL

Conditions

Summary

This study is designed to better understand the mechanisms contributing to impaired activation of leg muscles in people with Parkinson's disease (PD) and to test if stimulation of a nerve at the neck can improve muscle activation, walking and balance.


Eligibility

Min Age: 21 YearsMax Age: 76 Years

Plain Language Summary

Simplified for easier understanding

This study tests whether a gentle, non-invasive form of nerve stimulation (applied to the neck) can improve muscle activity and posture in people with Parkinson's disease. The device stimulates the vagus nerve through the skin without surgery. **You may be eligible if...** - You have been diagnosed with Parkinson's disease - Your medications have been stable for the past month and are expected to remain stable for 3 months - You can walk at least 50 meters without a walking aid - (For control group) You are similar in age and sex to Parkinson's participants **You may NOT be eligible if...** - You have another significant neurological condition besides Parkinson's - You have had a stroke, brain injury, aneurysm, or brain tumor - You have a serious bone or joint problem affecting your walking - You are pregnant or may be pregnant - You have neck pain, lesions, or previous neck surgery at the stimulation site - You have had a substance use problem in the past 2 years Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICEVagal nerve stimulation

The gammaCore non-invasive vagus nerve stimulator (nVNS) is a hand-held portable device that is used to apply electrical stimulation to the vagus nerve via two electrodes.

OTHERNo intervention

No nVNS is applied in the baseline experiment. Sham nVNS is applied for experiment two


Locations(1)

Movement Disorders Laboratory

Minneapolis, Minnesota, United States

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NCT07226284


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