RecruitingPhase 2Phase 3NCT07229651

Metformin in Parkinson Disease

Safety and Efficacy of Metformin in Patients With Parkinson Disaese

Sponsor

Tanta University

Enrollment

60 participants

Start Date

Nov 10, 2025

Study Type

INTERVENTIONAL

Conditions

Parkinson Disease

Summary

The clinical manifestations of Parkinson's disease (PD), a chronic neurodegenerative condition, include resting tremor, hypokinesia, bradykinesia, stiffness and postural instability. These motor symptoms are caused by a selective loss and degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNpc) region, which leads to a dopamine (DA) insufficiency in the striatum

Eligibility

Min Age: 50 YearsMax Age: 70 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether metformin, a common diabetes drug, can help slow the progression of Parkinson's disease. Researchers believe metformin may reduce inflammation and protect brain cells in people with Parkinson's. **You may be eligible if...** - You are a man or woman aged 50 or older - You have been diagnosed with Parkinson's disease - You are currently taking levodopa/carbidopa (a standard Parkinson's medication) **You may NOT be eligible if...** - Your Parkinson's symptoms are caused by another medical condition (secondary parkinsonism) - You have atypical Parkinson's-like conditions - You are taking anti-inflammatory medications - You have had brain surgery for Parkinson's - You are pregnant or breastfeeding - You have heart disease, blood clotting disorders, or active cancer - You have a serious alcohol or drug addiction Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGLevodopa Carbidopa

Carbidopa/levodopa, also known as levocarb and co-careldopa, is the combination of the two medications carbidopa and levodopa. It is primarily used to manage the symptoms of Parkinson's disease

DRUGMetformin

Metformin, sold under the brand name Glucophage, among others, is the main first-line medication for the treatment of type 2 diabetes, particularly in people who are overweight.