A Phase 1b Open-label Study to Evaluate Safety of Plamotamab in Participants With Rheumatoid Arthritis

This study is testing a new treatment for adults with moderate-to-severe rheumatoid arthritis — a condition where the immune system attacks the joints, causing pain and swelling. Researchers want to see if this new therapy is safe in people who haven't responded well to existing RA drugs. **You may be eligible if...** - You are an adult with a confirmed diagnosis of rheumatoid arthritis for at least 3 months - Your arthritis is moderately to severely active - Other RA treatments have not worked well enough, stopped working, or caused side effects you couldn't tolerate - You are on stable doses of your current RA medications - You use reliable birth control if applicable **You may NOT be eligible if...** - You have a major active infection (including tuberculosis or hepatitis B/C) - You have recently had a heart attack, stroke, or cancer - You have a weakened immune system for other reasons - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.