RecruitingNot ApplicableNCT07231471

Platelet Rich Plasma for Musculoskeletal Conditions

Sponsor

University of Utah

Enrollment

10,000 participants

Start Date

Dec 29, 2025

Study Type

INTERVENTIONAL

Conditions

Osteoarthritis (OA)

Summary

The primary purpose of this study is to follow patients with various musculoskeletal (MSK) conditions over a one-year follow-up period after receiving a platelet rich plasma (PRP) injection, assessing changes in their pain levels, functional abilities, and overall patient satisfaction. This will develop a robust registry of patients treated with PRP for a range of MSK conditions. These conditions include, but are not limited to, osteoarthritis (OA) of the knee, hip, glenohumeral joint, elbow, ankle, and sacroiliac joint, as well as rotator cuff tendinopathy, lateral and medial epicondylitis, plantar fasciitis, patellar tendinopathy, Achilles tendinopathy, and proximal hamstring tendinopathy.

Eligibility

Min Age: 18 Years

Inclusion Criteria3

+ years old
Musculoskeletal pathology that may benefit from a PRP injection
Failed other conservative treatments

Exclusion Criteria5

No active malignancy
No active infection in the area of injection
No platelet disorder
No active systemic infections
No patients currently undergoing dialysis

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Interventions

BIOLOGICALPlatelet Rich Plasma Injection

Participants who are eligible and provide consent to participate will undergo a Platelet-Rich Plasma (PRP) injection. Their blood will be analyzed using a cell counter, and they will be asked to complete follow-up surveys at 2 weeks, 6 weeks, 3 months, 6 months, and 12 months.

DEVICEPlatelet Rich Plasma Preparation

The patient's blood is collected into syringes. That blood is spun in a centrifuge at high speeds, which separates their blood into layers (red blood cells, white blood cells, and plasma). The plasma portion, which contains the platelets, is transferred to a different syringe for later injection. In some cases, the plasma is spun in the centrifuge again (a "double spin" technique) to further concentrate the platelets in the plasma. The patient's blood is not exposed to air, and it is transferred by tubing between syringes with a Luer Lock connection.