Osteoarthritis (OA) Clinical Trials

19 recruitingLast updated: May 21, 2026

There are 19 actively recruiting osteoarthritis (oa) clinical trials across 18 countries. Studies span Not Applicable, Phase 2, Phase 1, Phase 3, Phase 4. Top locations include Chicago, Illinois, United States, Ankara, Turkey (Türkiye), Athens, Greece. Updated daily from ClinicalTrials.gov.


Osteoarthritis (OA) Trials at a Glance

19 actively recruiting trials for osteoarthritis (oa) are listed on ClinicalTrialsFinder across 6 cities in 18 countries. The largest study group is Not Applicable with 7 trials, with the heaviest enrollment activity in Chicago, Ankara, and Athens. Lead sponsors running osteoarthritis (oa) studies include University of Chicago, CEN Biotech, and Bartın Unıversity.

Browse osteoarthritis (oa) trials by phase

About Osteoarthritis (OA) Clinical Trials

Looking for clinical trials for Osteoarthritis (OA)? There are currently 6 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Osteoarthritis (OA) trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Osteoarthritis (OA) clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 119 of 19 trials

Recruiting
Phase 3

A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee Osteoarthritis Lose Weight and Reduce Pain

ObesityKnee osteoarthritis (OA)
Novo Nordisk A/S400 enrolled82 locationsNCT07481630
Recruiting

Creation of a Prospective Data Collecting Registry for Genicular Artery Embolization for Arthritis

Knee OsteoarthritisKnee Osteoarthritis (Knee OA)Knee osteoarthritis (OA)
University of Chicago100 enrolled1 locationNCT06781463
Recruiting
Not Applicable

Platelet Rich Plasma for Musculoskeletal Conditions

Osteoarthritis (OA) of the hipOsteoarthritis (OA)Osteoarthritis Ankle+6 more
University of Utah10,000 enrolled1 locationNCT07231471
Recruiting

Screening for Biomarkers of Osteoarthritis

Osteoarthritis (OA)
The First Affiliated Hospital of Xinxiang Medical College300 enrolled1 locationNCT07544823
Recruiting

PENG Block & PENG PRF

Osteoarthritis (OA) of the hip
Ankara City Hospital Bilkent84 enrolled1 locationNCT07360093
Recruiting
Phase 1Phase 2

Recombinant Human Growth Hormone (rHGH) for Knee Osteoarthritis (KORR)

Knee Osteoarthritis (Knee OA)Knee osteoarthritis (OA)
Dr. David Wasserstein34 enrolled1 locationNCT07036003
Recruiting

Ultrasonographic Evaluation of Talar Cartilage Thickness in Patients With Spinal Cord Injury

Osteoarthritis (OA)Spinal Cord Injuries (SCI)
Gaziosmanpasa Research and Education Hospital76 enrolled1 locationNCT07293949
Recruiting
Not Applicable

The Effectiveness of a Herbal Supplement in Osteoarthritis.

Osteoarthritis (OA) of the hipOsteoarthritis (OA)Osteoarthritis+1 more
Middlesex University30 enrolled1 locationNCT07324746
Recruiting

Individual Differences in Gait and Osteoarthritis Pain

Chronic PainChronic Knee PainKnee osteoarthritis (OA)
University of Pittsburgh300 enrolled1 locationNCT07308873
Recruiting
Not Applicable

Effects of Different Relaxation Therapies on Pain and Sleep in Hip and Knee Arthroplasty Patients

Osteoarthritis (OA) of the hipOsteoarthritis(OA) of the knee
Bartın Unıversity82 enrolled1 locationNCT07354542
Recruiting
Not Applicable

A Clinical Study to Evaluate the Efficacy of Native CT-II® in Individuals With Knee Osteoarthritis

Knee osteoarthritis (OA)
Vedic Lifesciences Pvt. Ltd.114 enrolled5 locationsNCT06917287
Recruiting

Does Surgical Treatment of Cartilage Defects Prevent Osteoarthritis in Later Life?

Osteoarthritis (OA)
Robert Jones and Agnes Hunt Orthopaedic and District NHS Trust650 enrolled2 locationsNCT07320118
Recruiting
Phase 2

The Effect and Safety of Anti-inflammatories and Dextrose Prolotherapy Injections in Treating Knee Osteoarthritis

Knee osteoarthritis (OA)
David Grant U.S. Air Force Medical Center68 enrolled1 locationNCT06911359
Recruiting
Not Applicable

Gait After THA: Direct Anterior vs Manual Posterior vs Robotic Posterior

Osteoarthritis (OA) of the hip
Ochsner Health System48 enrolled2 locationsNCT07226973
Recruiting
Not Applicable

Knee Osteoarthritis and Spa Therapy

Knee OsteoarthritisKnee osteoarthritis (OA)
CEN Biotech80 enrolled1 locationNCT06617975
Recruiting

Evaluation of the effectiveness of an eLearning program for health professionals managing people with osteoarthritis: a mixed methods prospective cohort study and randomised trial

Osteoarthritis (OA)
The University of Sydney102 enrolled4 locationsACTRN12625000787482
Recruiting
Phase 2

Genicular Artery Embolization for Reducing Pain in Medically Refractory Symptomatic Knee Osteoarthritis

Knee OsteoarthritisKnee Osteoarthritis (Knee OA)Knee osteoarthritis (OA)
University of Chicago50 enrolled1 locationNCT06859164
Recruiting
Phase 4

Systemic Oral Glucocorticoids for the Treatment of Acute Osteoarthritis Pain in the Emergency Department

Osteoarthritis (OA) of the hipOsteoarthritisOsteoarthritis (OA) of the Shoulder+1 more
WellSpan Health192 enrolled1 locationNCT06603662
Recruiting
Not Applicable

Effects of Core Stabilization Exercises Versus Foot-Ankle Strengthening Program in Patients With Knee Osteoarthritis.

Knee osteoarthritis (OA)
Riphah International University46 enrolled1 locationNCT06658249