[18F]FT8 PET Imaging in Immunoglobulin Light Chain Amyloidosis
Clinical Study of [18F]FT8 PET/CT in Evaluating Amyloidosis
Tianjin Medical University
25 participants
Jul 21, 2025
OBSERVATIONAL
Conditions
Summary
\[18F\]FT8, a derivative of 1-(4-pyridyl)-4-piperazinyl arene (\[18F\]TPZA), exhibits high affinity for AL amyloid in myocardial tissue sections and shows no significant binding to transthyretin amyloid. By comparing its diagnostic performance against established clinical methods, including echocardiography, contrast-enhanced MRI, and relevant laboratory tests, this study aims to establish \[18F\]FT8 as the basis for a robust PET protocol for the direct visualization and differential diagnosis of AL amyloidosis . The study preimarily evaluates the safety and diagnostic efficacy of \[18F\]FT8 PET imaging in human subjects.
Eligibility
Plain Language Summary
Simplified for easier understanding
This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.
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Interventions
Each subject will receive a single intravenous injection of \[18F\]FT8 and will undergo PET imaging at a specified time.
Locations(2)
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NCT07232459