Amyloid Clinical Trials

4 recruiting

Frequently Asked Questions

Common questions about Amyloid clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 41 trials

Recruiting
Phase 3

CLEOPATTRA: A Research Study to Look at the Effects of Treatment With a Medicine Called Coramitug (NNC6019-0001) in People With Heart Failure Due to Transthyretin Amyloid (ATTR) Amyloidosis

Transthyretin Amyloid Cardiomyopathy (ATTR CM)
Novo Nordisk A/S1,280 enrolled285 locationsNCT07207811
Recruiting
Phase 1

A Study of JNJ-79635322 in Participants With Relapsed or Refractory Multiple Myeloma or Previously Treated Amyloid Light-chain (AL) Amyloidosis

Relapsed or Refractory Multiple MyelomaPreviously Treated Amyloid Light-chain (AL) Amyloidosis
Janssen Research & Development, LLC180 enrolled29 locationsNCT05652335
Recruiting
Phase 3

Acoramidis Transthyretin Amyloidosis Prevention Trial in the Young (ACT-EARLY) Study in Asymptomatic Carriers of a Pathogenic TTR Variant

CardiomyopathiesAmyloidosisHeart Diseases+3 more
Eidos Therapeutics, a BridgeBio company582 enrolled94 locationsNCT06563895
Recruiting

One Gene, Two Diseases: the Pathologic Role of IGLV1-44 in AL Amyloidosis and POEMS

Multiple MyelomaAL AmyloidosisPOEMS Syndrome
Fondazione IRCCS Policlinico San Matteo di Pavia100 enrolled1 locationNCT07448935
Recruiting

Investigating the Pathogenic Role of N-glycosylation in AL Amyloidosis: Molecular Bases, Diagnosis, and Treatment

Multiple MyelomaMGUSAL Amyloidosis+1 more
Fondazione IRCCS Policlinico San Matteo di Pavia100 enrolled1 locationNCT07448779
Recruiting
Phase 1

A Trial Evaluating the Effect of NIO752 on Tau Synthesis Measured by a Process Known as SILK

Alzheimer DiseaseAutosomal Dominant Alzheimer Disease Due to Mutation of Presenilin 1 (Disorder)Autosomal Dominant Alzheimer Disease Due to Mutation of Presenilin 2 (Disorder)+1 more
University College, London10 enrolled2 locationsNCT06372821
Recruiting

Institutional Registry of Rare Diseases

ParagangliomaPheochromocytomaAmyloidosis+23 more
Hospital Italiano de Buenos Aires380 enrolled1 locationNCT06573723
Recruiting

A Study to Learn About the Use of Acoramidis in Patients With a Heart Condition Called Transthyretin Amyloid Cardiomyopathy (ATTR-CM) in a Real-world Setting

Transthyretin Amyloid Cardiomyopathy (ATTR CM)
Bayer2,000 enrolled1 locationNCT07235462
Recruiting
Phase 2

Minimal Residual Disease Response-adapted Deferral of Transplant in Dysproteinemia (MILESTONE)

Multiple MyelomaAmyloidosis
University of Alabama at Birmingham40 enrolled1 locationNCT04991103
Recruiting

Generative AI Impact on Rheumatoid Arthritis Complications Diagnosis

Cardiovascular DiseasesOsteoporosisThrombosis+12 more
Guang'anmen Hospital of China Academy of Chinese Medical Sciences100 enrolled1 locationNCT07301892
Recruiting
Phase 2

The Cancer Connected Access and Remote Expertise Beyond Walls Program to Provide In-Home Cancer Treatment and Improve Treatment Satisfaction in Cancer Patients Living in the Florida Panhandle and Surrounding Areas

Breast CarcinomaUrothelial CarcinomaOvarian Carcinoma+26 more
Mayo Clinic27 enrolled1 locationNCT07285044
Recruiting
Early Phase 1

Time-in-bed Restriction in Older Adults With Sleep Difficulties With and Without Risk for Alzheimer's Disease

Cognitive ChangeSleepMild Cognitive Impairment+2 more
University of Pittsburgh116 enrolled1 locationNCT05138848
Recruiting
Phase 1Phase 2

A Study to Assess the Effects of ACI-24.060 in Alzheimer's Disease and in Down Syndrome (ABATE Study)

Alzheimer s DiseaseBeta-AmyloidProdromal Alzheimer's Disease+2 more
AC Immune SA176 enrolled19 locationsNCT05462106
Recruiting

Cancer and Aging Resilience Evaluation in Older Adults With Hematologic Malignancies: The CARE-Heme Registry

Multiple MyelomaAmyloidosisPlasma Cell Leukemia
University of Alabama at Birmingham5,000 enrolled1 locationNCT05556928
Recruiting

Cardiac Amyloidosis pRevaleNce of in OLDer Subjects Affected by Heart Failure

Cardiac Amyloidosis
Gérond'if637 enrolled36 locationsNCT06427304
Recruiting

Registry for Adults With Plasma Cell Disorders (PCD's)

Multiple MyelomaAmyloidosisSmoldering Multiple Myeloma+6 more
UNC Lineberger Comprehensive Cancer Center2,000 enrolled1 locationNCT03717844
Recruiting

[18F]FT8 PET Imaging in Immunoglobulin Light Chain Amyloidosis

AmyloidosisCardiac AmyloidosisHealthy Subjects+1 more
Tianjin Medical University25 enrolled2 locationsNCT07232459
Recruiting

US Benchmarking Clinical Study

Cardiac AmyloidosisHFpEF - Heart Failure With Preserved Ejection FractionHFmrEF+2 more
eMyosound SAS150 enrolled3 locationsNCT07215715
Recruiting
Phase 1Phase 2

A Trial to Learn if Linvoseltamab is Safe and Works in Adults With Relapsed or Refractory Systemic Light Chain Amyloidosis (AL Amyloidosis)

Relapsed/Refractory Systemic Light Chain Amyloidosis
Regeneron Pharmaceuticals220 enrolled18 locationsNCT06292780
Recruiting

Cardiac Amyloid Deposits and Heart Dysfunction in Alzheimer's Disease

Mild Cognitive ImpairmentCardiac AmyloidosisDementia Alzheimer Type
University Hospital, Essen15 enrolled1 locationNCT07154394