RecruitingNot ApplicableNCT07258875

Effect of VExUS Ultrasound Protocol (Venous Excess Ultrasound) on Perioperative Fluid Management, on the Incidence of Postoperative Pulmonary Complications and Postoperative Acute Kidney Injury in Patients Undergoing Thoracic Surgery


Sponsor

University of Crete

Enrollment

230 participants

Start Date

Nov 27, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

This study aims to investigate the effect of a VExUS ultrasound guided protocol of perioperative fluid management within a goal-directed therapy framework, on postoperative respiratory complications, and the occurrence of acute kidney injury (AKI) in patients undergoing thoracic surgery.


Eligibility

Min Age: 18 Years

Inclusion Criteria1

  • Adults \>18 years undergoing video assisted thoracic surgery/ lobectomy requiring one-lung ventilation.

Exclusion Criteria8

  • Refusal to participate.
  • Pneumonectomy.
  • Young athletes (risk of physiologically large IVC \>2 cm).
  • Moderate-severe tricuspid regurgitation, moderate to severe pulmonary hypertension
  • Heart failure with reduced ejection fraction, EF\<35%
  • Portal hypertension, portal vein thrombosis, or liver cirrhosis.
  • Stage 4 or end-stage chronic kidney disease (eGFR \<30 mL/min/1.73 m² or dialysis).
  • Transfusion with more than 2 packed red blood cells unit perioperatively (intraoperatively, in the PACU, in the ward)

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Interventions

DIAGNOSTIC_TESTVenous Excess Ultrasound

The VExUS protocol is a standardized point-of-care ultrasound examination that includes measurements of the inferior vena cava (IVC) diameter, combined with Doppler analysis of waveforms in the hepatic vein, portal vein, and renal veins. From this analysis, the presence of venous congestion-classified as mild or severe-or its absence is determined. A high VExUS score (grade 3) has been strongly associated with the occurrence of acute kidney injury in patients undergoing cardiac surgery and has more recently been linked to elevated right atrial pressure (RAP ≥ 12 mmHg). The protocol includes the following classification: * Grade 0: IVC \< 2 cm * Grade 1: IVC ≥ 2 cm, with normal or mildly abnormal waveforms in the hepatic, portal, and renal veins (mild congestion) * Grade 2: IVC ≥ 2 cm, with severely altered waveforms in at least one vein (moderate congestion) * Grade 3: IVC ≥ 2 cm, with severely altered waveforms in multiple veins (severe congestion)

OTHERStandard of Care (SOC)

Intraoperatively patients of the control group will be administered isotonic crystalloids (Lactated Ringer's, Plasma-Lyte) at a rate of 3 mL/kg/h.Fluid administration will continue at a rate of 3 mL/kg/h as per standard practice in the PACU.


Locations(1)

University General Hospital of Heraklion

Heraklion, Crete, Greece

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NCT07258875


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