RecruitingNot ApplicableNCT07268495

The Impact of Intraperitoneal Spray Combined With Intravenous Lidocaine on Postoperative Pain After Myomectomy

Sponsor

General Hospital of Ningxia Medical University

Enrollment

100 participants

Start Date

Aug 1, 2024

Study Type

INTERVENTIONAL

Conditions

Postoperative Pain

Summary

The purpose of this study is to determine whether laparoscopic spraying combined with intravenous injection of lidocaine can improve pain in patients undergoing laparoscopic myomectomy under general anesthesia.

Eligibility

Sex: FEMALEMin Age: 18 YearsMax Age: 65 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether combining lidocaine (a local anesthetic) sprayed into the abdomen during surgery with intravenous (IV) lidocaine can better reduce pain after laparoscopic surgery to remove uterine fibroids (myomectomy). **You may be eligible if...** - You are between 18 and 65 years old - You are scheduled for laparoscopic (keyhole) surgery to remove uterine fibroids under general anesthesia - You are otherwise in acceptable health for surgery (ASA class I–III) **You may NOT be eligible if...** - Your surgery is expected to last more than 3 hours - You need additional procedures beyond fibroid removal - You are allergic to lidocaine or the other study drugs - You have severe psychological, liver, kidney, or heart disease - You have a history of chronic pain or abnormal heart rhythms (arrhythmia) - Your surgery needs to be converted from laparoscopic to open surgery during the procedure Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGSaline

10 minutes before the infusion saline 1.5mg/kg was administered to the patient. Subsequnetly, a continuous intravenous infusion saline 2mg/kg/h was maintained until the end of the sugery. Before closing the abdominal cavity, 20ml normal saline was administered.

DRUGintravenous +saline lidocaine

10 minutes before the infusion 2% lidocaine 1.5mg/kg was administered to the patient. Subsequnetly, a continuous intravenous infusion 2% lidocaine 2mg/kg/h was maintained until the end of the sugery. Before closing the abdominal cavity, 20ml normal saline was administered.

DRUGsaline + intraperitoneal lidocaine

10 minutes before the infusion saline 1.5mg/kg was administered to the patient. Subsequnetly, a continuous intravenous infusion saline ( 2mg/kg/h) was maintained until the end of the sugery. Before closing the abdominal cavity, 2% lidocaine (4-5mg/kg) + 1/200,000 epinephrine was spraged into the abdominal cavity.

DRUGintravenous + intraperitoneal lidocaine

10 minutes before the infusion 2% lidocaine (1.5mg/kg) was administered to the patient. Subsequnetly, a continuous intravenous infusion 2% lidocaine ( 2mg/kg/h) was maintained until the end of the sugery. Before closing the abdominal cavity, 2% lidocaine (4-5mg/kg) + 1/200,000 epinephrine was spraged into the abdominal cavity.