RecruitingNot ApplicableNCT07270757

Impact of Pre-Ablation Prehabilitation on Clinical Outcomes and Cardiorespiratory Fitness in Atrial Fibrillation Patients

Impact of Pre-Ablation Prehabilitation on Clinical Outcomes and Cardiorespiratory Fitness in Patients With Atrial Fibrillation: A Randomized Controlled Trial

Sponsor

Nanjing Medical University

Enrollment

100 participants

Start Date

Feb 1, 2025

Study Type

INTERVENTIONAL

Conditions

Atrial Fibrillation (AF)

Summary

The primary objective of this study is to compare the effects of a preoperative prehabilitation program versus usual care on post-procedural cardiorespiratory function and clinical outcomes in patients undergoing catheter ablation for atrial fibrillation.

Eligibility

Min Age: 18 YearsMax Age: 70 Years

Inclusion Criteria4

Aged 18-70 years
Scheduled for first AF ablation
NYHA class I-II
LVEF ≥ 50%

Exclusion Criteria3

Significant structural heart disease (e.g., severe valvular disease)
Contraindications to CPET or exercise training
Cognitive impairment preventing cooperation

Interventions

OTHER4-week structured prehabilitation program (exercise training + psychological education)

The prehabilitation group will receive a 4-week structured program before ablation, including: Individualized exercise training: Prescription based on cardiopulmonary exercise test results, including aerobic exercise (40%-60% of heart rate reserve) and resistance training Psychological and educational intervention: Structured education based on cognitive behavioral therapy principles, focusing on addressing kinesiophobia Delivery mode: Hybrid (supervised in-hospital sessions + monitored home-based sessions) The usual care group will receive only standard preoperative education without structured rehabilitation.