RecruitingNot ApplicableNCT07271082

Efficacy and Safety of Home-based Structured Physical Exercise in Patients With Acute Ischemic Stroke

Efficacy and Safety of Home-based Structured Physical Exercise in Patients With Acute Ischemic Stroke: a Randomized Controlled, Open-label, Blinded Endpoint Trial-2 (HOPE-STROKE 2)

Sponsor

Capital Medical University

Enrollment

208 participants

Start Date

Dec 18, 2025

Study Type

INTERVENTIONAL

Conditions

Acute Ischemic Stroke

Summary

This study is a randomized controlled, open-label, blinded endpoint trial. The investigators aim to assess the efficacy and safety of home-based structured physical exercise in participants with acute ischemic stroke.

Eligibility

Min Age: 18 Years

Inclusion Criteria4

Age 18 years or greater, male or female;
Acute ischemic stroke onset within 14 days;
modified Rankin scale (mRS) score ≤ 3;
Signed informed consent from the patients or the legally authorized representatives.

Exclusion Criteria10

Stroke progression within the past 3 days (defined as an increase in NIHSS score of ≥4 points or an increase in any single item of ≥2 points);
Concurrent osteoarthritis, fractures, deep vein thrombosis, unstable angina, severe heart diseases, respiratory diseases, or amputation that may theoretically make it difficult for participants to complete the physical exercise or ambulation;
Concurrent movement disorders such as Parkinson's disease or Parkinsonism;
Patients who have engaged in regular aerobic physical activity within the past 6 months, defined as more than 150 minutes of moderate-intensity aerobic physical activity; or more than 75 minutes of vigorous-intensity aerobic physical activity; or an equivalent combination of moderate- and vigorous-intensity activity throughout the week;
Unable to comply with the study procedures or follow-up due to psychiatric, cognitive, or emotional disorders;
Known pregnancy or lactation, or a positive pregnancy test;
Currently participating in another drug or device study;
Life expectancy less than 1 year;
Unable to communicate using a smartphone;
Other conditions considered by investigators to be unsuitable for inclusion.