RecruitingNot ApplicableNCT07271472

Oxidative Stress Effects of TIVA, CIVA, and Balanced Anesthesia in VATS

Total Intravenous Anesthesia (TIVA), Combined Intravenous-Volatile Anesthesia (CIVA), and Balanced Anesthesia (BAL) on Perioperative Oxidative Stress in Video-Assisted Thoracoscopic Surgery (VATS)

Sponsor

Ataturk University

Enrollment

60 participants

Start Date

Dec 1, 2025

Study Type

INTERVENTIONAL

Conditions

VATS

Summary

The primary objective of our study is to compare the effects of total intravenous anesthesia (TIVA), combined intravenous-volatile anesthesia (CIVA), and balanced anesthesia (BAL) methods on perioperative oxidative stress parameters, such as Malondialdehyde (MDA), Total Oxidant Status (TOS), Total Antioxidant Status (TAS), and Superoxide Dismutase (SOD), in patients undergoing video-assisted thoracoscopic surgery (VATS). The secondary objective is to record perioperative vital parameters, arterial blood gas values obtained at specific stages of the surgery, and the incidence of postoperative nausea and vomiting (PONV).

Eligibility

Min Age: 18 YearsMax Age: 65 Years

Inclusion Criteria4

Aged between 18 and 65 years,
American Society of Anesthesiologists (ASA) Physical Status Class I-II,
Scheduled for elective Video-Assisted Thoracoscopic Surgery (VATS)
Requiring one-lung ventilation for more than 60 minutes

Exclusion Criteria5

Refusal to participate in the study
History of allergy to the drugs to be used
Recent history of vitamin supplementation
History of severe cardiac, renal, or hepatic disease
ASA III-IV

Print for Your Doctor

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

DRUGTotal Intravenous Anesthesia (TIVA) Group

Anesthesia induction will include 2 mg midazolam, 2-2.5 mg/kg propofol, 0.6-0.9 mg/kg rocuronium, and 1 μg/kg remifentanil. Maintenance will be provided with target-controlled infusion (TCI) propofol at a Ce of 4-6 μg/mL and TCI remifentanil at a Ce of 1.5-3 ng/mL while maintaining the bispectral index (BIS) between 40-60.

DRUGBalanced Anesthesia (BAL) Group

Induction will follow the same protocol as the TIVA group. During maintenance, desflurane 5-7% (MAC 1-1.3) and TCI remifentanil at a Ce of 1.5-3 ng/mL will be administered, targeting a BIS value between 40-60.

DRUGCombined Intravenous Volatile Anesthesia

Induction will follow the same protocol as other groups. Maintenance will include TCI propofol at a Ce of 2-4 μg/mL and TCI remifentanil at a Ce of 1.5-3 ng/mL along with 3% desflurane (MAC 0.5), keeping BIS values between 40-60.