Pregnancy and Fibrin Clot Properties
Fibrin Clot Properties and Thrombin Generation in Pregnancy Women With and Without Obstetric Complications.
Jagiellonian University
100 participants
Nov 28, 2025
OBSERVATIONAL
Conditions
Summary
1. The structure of fibrin clot and thrombin generation may vary between trimesters of pregnancy. 2. Unfavorably altered fibrin clot properties along with enhanced thrombin generation may lead to the development of complications during pregnancy such as TE and hypertensive disorders. 3. The application of machine learning techniques may help to identify previously undetected phenotypes with increased risk of TE and hypertensive disorders during pregnancy.
Eligibility
Inclusion Criteria1
- I. age 18-40 years; II. natural conception (without assisted reproductive techniques).
Exclusion Criteria1
- I. use of hormonal therapy (i.e., oral contraceptives, progestogens) within 3 months before or during pregnancy; II. use of anticoagulants oral/subcutaneous within 3 months before or during pregnancy; III. increased risk factors of VTE (i.e., obesity - body mass index \>30 kg/m2; smoking) or history of VTE; IV. Concomitant diseases, i.e: severe hypertension, diabetes mellitus, autoimmune diseases (i.e., systemic lupus erythematosus, antiphospholipid syndrome); V. congenital or acquired thrombophilia (i.e., mutation factor V Leiden, prothrombin mutation).
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Interventions
determination of fibrin clot properties and thrombin generation
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT07275476