Combined Brain Stimulation and Methylphenidate Treatment for Apathy in Dementia

This trial is testing a combination of brain stimulation (TMS — a non-invasive device that uses magnetic pulses to stimulate brain activity) and methylphenidate (a medication that may boost motivation) to treat apathy — a loss of interest and motivation — in people with Alzheimer's disease or mixed dementia. **You may be eligible if...** - You have been diagnosed with Alzheimer's disease or mixed Alzheimer's and vascular dementia - Your cognitive test score (MMSE) is between 10 and 28 - You have clinically significant apathy (low motivation and engagement) - Your psychotropic medications have been stable - A care partner spends at least 10 hours per week with you **You may NOT be eligible if...** - You are currently experiencing a major depressive episode - You have significant agitation, delusions, or hallucinations - You are taking other dopaminergic medications (like levodopa) besides methylphenidate - You have a pacemaker, metallic implants, or a history of epilepsy (which would make TMS unsafe) - You have other significant neurological conditions beyond dementia Talk to your doctor to see if this trial is right for you.