Prospective Evaluation of the Pulse Biosciences nPulse™ Vybrance™ Percutaneous Electrode System

This trial is evaluating a new device called the nPulse Vybrance system, which uses short electrical pulses to destroy benign (non-cancerous) thyroid nodules without surgery. **You may be eligible if...** - Your thyroid nodule has been confirmed as benign (non-cancerous) by at least one fine needle aspiration or biopsy, or two biopsies - Your nodule can be approached safely through a specific technique (trans-isthmus approach) - You are willing and able to attend all follow-up visits - You can provide written informed consent **You may NOT be eligible if...** - Your thyroid nodule has not been confirmed as benign - The nodule is not accessible for the required procedure technique - You have signs of cancer or suspicious features on ultrasound that have not been cleared by biopsy - You are not able to comply with study procedures Talk to your doctor to see if this trial is right for you.