RecruitingPhase 4NCT07288801

Vitamin D for Preventing Recurrent Preeclampsia in Pregnant Women

Role of Vitamin D in Prevention of Preeclampsia Recurrence in Pregnant Women With Previous History of Preeclampsia: A Randomized Controlled Trial


Sponsor

Nishtar Medical University

Enrollment

146 participants

Start Date

Aug 9, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

The goal of this clinical trial is to find out whether giving vitamin D to pregnant women who had pre-eclampsia in a previous pregnancy helps prevent the condition from coming back. The main question it aims to answer is: Does vitamin D supplementation reduce the chance of pre-eclampsia recurring in pregnant women with a history of pre-eclampsia? To answer this question, pregnant women attending the antenatal clinic at the Department of Obstetrics and Gynaecology, Nishtar Hospital Multan will be invited to join the study. Participants will be randomly assigned to two equal groups: * Vitamin D group: will take 4,000 IU of oral vitamin D until 36 weeks of gestation. * Placebo group: will receive a pill identical in appearance, taste, and consistency but without vitamin D. While on the study medication, each woman will visit the clinic every two weeks. At each visit, her blood pressure will be measured, and if it is 140/90 mmHg or higher, a urine test will check for protein to identify pre-eclampsia as per hospital protocol. Any diagnosis of pre-eclampsia will lead to standard care, and the outcome will be recorded. At the end, researchers will compare how many women in each group developed recurrent pre-eclampsia. This study will help answer whether vitamin D supplementation can safely reduce the risk of pre-eclampsia returning in women with a prior history - a question important for improving pregnancy outcomes and maternal health.


Eligibility

Sex: FEMALEMin Age: 20 YearsMax Age: 45 Years

Plain Language Summary

Simplified for easier understanding

This trial is investigating whether taking vitamin D supplements during pregnancy can reduce the chances of preeclampsia — a dangerous condition involving high blood pressure and organ stress — in women who have experienced preeclampsia in a previous pregnancy and are therefore at higher risk of it happening again. **You may be eligible if...** - You are currently pregnant and at least 20 weeks along (based on your last menstrual period) - You have a history of preeclampsia in a previous pregnancy, putting you at higher risk this time - You are otherwise able and willing to participate in the study **You may NOT be eligible if...** - You have pre-existing high blood pressure (hypertension) before pregnancy - You have a pre-existing heart condition, kidney disease, or an overactive thyroid gland (thyrotoxicosis) - Your baby has already died in the womb (intrauterine fetal death) - You have a medical condition that your doctor feels makes participation unsafe Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGVitamin D

4000 IU of vitamin D will be given orally, once daily till 36-weeks of gestation

DRUGPlacebo and standard of care

Look, smell and taste alike oil emulsion drops, same number, till 36-weeks of gestation


Locations(1)

Nishtar Medical University and Hospital

Multan, Punjab Province, Pakistan

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NCT07288801


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