RecruitingPhase 3NCT07293260

Olpasiran Trials of Cardiovascular Events and Lipoprotein(a) Reduction - Coronary Computed Tomography Angiography Trial

A Double-blind, Randomized, Placebo-controlled, Multi-center Study Evaluating the Safety, Tolerability, and Effect of Olpasiran on Coronary Artery Plaque Burden Assessed by Coronary Computed Tomography Angiography in Participants With Stable Atherosclerotic Cardiovascular Disease and Elevated Lipoprotein(a)

Sponsor

Amgen

Enrollment

406 participants

Start Date

Mar 23, 2026

Study Type

INTERVENTIONAL

Conditions

Cardiovascular Disease

Summary

The primary objective of this trial is to evaluate the effect of olpasiran, compared to placebo, on non-calcified plaque (NCP) volume as measured by Coronary Computed Tomography Angiography (CCTA).

Eligibility

Min Age: 35 YearsMax Age: 80 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called Olpasiran and a drug called Placebo for people with cardiovascular disease. The study is currently recruiting participants at 40 locations. People eligible for this study include aged 35 Years to 80 Years.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGOlpasiran

Olpasiran will be administered SC.

DRUGPlacebo

Placebo will be administered SC.

Locations(40)

Bridgeport Hospital

Bridgeport, Connecticut, United States

Jacksonville Center for Clinical Research

Jacksonville, Florida, United States

Midwest Heart and Vascular Specialists

Overland Park, Kansas, United States

Flourish Bowie

Bowie, Maryland, United States

Montefiore Medical Center - Bronx

Philadelphia, Pennsylvania, United States

Vital Heart and Vein

Humble, Texas, United States

Advara HeartCare Wesley

Auchenflower, Queensland, Australia

University of The Sunshine Coast Clinical Trials, Sippy Downs

Sippy Downs, Queensland, Australia

Advara HeartCare Leabrook

Leabrook, South Australia, Australia

North York Diagnostic and Cardiac Centre

Vaughan, Ontario, Canada

Peking University First Hospital

Beijing, Beijing Municipality, China

The First Affiliated Hospital of Zhengzhou University

Zhengzhou, Henan, China

The Second Xiangya Hospital of Central South University

Changsha, Hunan, China

The Third Xiangya Hospital of Central South University

Changsha, Hunan, China

The Second Affiliated Hospital of Nanjing Medical University

Nanjing, Jiangsu, China

General Hospital of Ningxia Medical University

Yinchuan, Ningxia, China

Shaanxi Provincial Peoples Hospital

Xi'an, Shaanxi, China

Jinan Central Hospital

Jinan, Shandong, China

Regionshospitalet Gødstrup

Herning, Denmark

Regionshospitalet Viborg

Viborg, Denmark

Centre Hospitalier Universitaire de Nice - Hopital Pasteur

Nice, France

Centre Hospitalier Universitaire de Bordeaux Hopital Haut-Leveque

Pessac, France

Centre Hospitalier Universitaire de Toulouse - Hopital Rangueil

Toulouse, France

Centre Hospitalier Regional Universitaire de Tours - Hopital Trousseau

Tours, France

Charite - Universitaetsmedizin Berlin, Campus Benjamin Franklin

Berlin, Germany

Universitaetsklinikum Essen

Essen, Germany

Universitaetsklinikum Frankfurt

Frankfurt am Main, Germany

Klinikum rechts der Isar der TUM

München, Germany

Azienda Ospedaliera Universitaria di Ferrara Arcispedale Sant Anna

Ferrara, Italy

IRCCS Centro Cardiologico Monzino

Milan, Italy

IRCCS Policlinico San Donato

San Donato Milanese, Italy

Azienda Ospedaliera Ordine Mauriziano di Torino

Torino, Italy

Tomakomai City Hospital

Tomakomai-shi, Hokkaido, Japan

Osaka Keisatsu Hospital

Osaka, Osaka, Japan

University of Yamanashi Hospital

Chuo-shi, Yamanashi, Japan

Tergooiziekenhuizen, locatie Hilversum

Hilversum, Netherlands

Hospital Universitario Virgen Macarena

Seville, Andalusia, Spain

Hospital Alvaro Cunqueiro

Vigo, Galicia, Spain

Hospital Universitari i Politecnic La Fe

Valencia, Valencia, Spain

Hospital Universitario Ramon y Cajal

Madrid, Spain

View Full Details on ClinicalTrials.gov

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NCT07293260

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