RecruitingNot ApplicableNCT07309198

Temporal Interference Stimulation on Motor Symptoms in Parkinson's Disease

Effects and Mechanisms of Non-invasive Deep Brain Stimulation in Patients With Parkinson's Disease

Sponsor

Shanghai University of Sport

Enrollment

36 participants

Start Date

Dec 29, 2025

Study Type

INTERVENTIONAL

Conditions

Parkinson's Disease

Summary

The goal of this clinical trial is to learn whether a type of brain stimulation called transcranial temporal interference stimulation (TIS) of the internal globus pallidus (GPi) can help improve movement symptoms in people with Parkinson's disease. The study will also look at how TIS changes brain activity related to these improvements. The main questions this study aims to answer are: * How much can repeated TIS sessions improve movement symptoms in people with Parkinson's disease? * Can these improvements last for up to two months after the treatment ends? * What changes in brain activity happen along with the improvements? Researchers will compare people who receive active TIS with those who receive sham (placebo-like) stimulation to see whether active TIS leads to better movement outcomes. Participants will: * Receive 10 sessions of active or sham TIS over two weeks * Complete movement assessments during the two-week treatment and again 2, 4, and 8 weeks afterward * Complete brain activity assessments before and after the two-week treatment

Eligibility

Min Age: 50 YearsMax Age: 80 Years

Plain Language Summary

Simplified for easier understanding

This study tests temporal interference stimulation (TIS) — a non-invasive brain stimulation technique that uses two low-intensity electrical fields to target deep brain structures — as a potential treatment to reduce motor symptoms in people with Parkinson's disease. **You may be eligible if...** - You have been diagnosed with idiopathic Parkinson's disease (the most common form) by a physician, with symptom onset after age 40 - Your Parkinson's medication (including levodopa) has been stable for at least 4 weeks - Your disease is at Hoehn & Yahr stage 1.5 to 3, and you can walk unassisted - You have a Montreal Cognitive Assessment (MoCA) score of 21 or higher (showing adequate cognitive function) **You may NOT be eligible if...** - You have any contraindication to MRI or transcranial electrical stimulation (such as metal implants in the head) - You have dementia or significant cognitive impairment - Your disease stage is too severe for unassisted walking Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICETranscranial Temporal Interference Stimulation (TIS)

Transcranial temporal interference stimulation (TIS) is a noninvasive brain stimulation technique that delivers two high-frequency alternating currents through scalp electrodes to generate a low-frequency interference field in deep brain regions. In this study, TIS targets the internal globus pallidus (GPi) to modulate neural activity in people with Parkinson's disease. Participants receive 10 stimulation sessions over two weeks. The sham TIS condition uses the same setup but applies low-frequency currents without generating an interference pattern.

Locations(1)

Shanghai University of Sport

Shanghai, Shanghai Municipality, China

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NCT07309198

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