Sucrase-Isomaltase (SI) Genes and Meal Load
Comparison of a Meal Load Between Normal and Functional Variants of the Sucrase-isomaltase (SI) Gene in IBS
Region Skane
70 participants
Feb 1, 2026
INTERVENTIONAL
Conditions
Summary
The goal of this interventional study is to examine whether those patients with irritable bowel syndrome (IBS) and a reduced abitility do degrade starch and sugar (lowe levels of enzymes) have lower raise in blood glucose after a meal than those with normal expression of enzymes. We also want to examine whether those IBS patients with reduced enzyme levels have increased bowel symptom in relation to this meal. The main questions it aims to answer are: Does reduced ability to degrade starch and sugar due to less enzyme activity lead to lower increase in blood glucose after a meal? Does reduced ability to degrade starch and sugar due to less enzyme activity lead to increased bowel symptoms after a meal?
Eligibility
Inclusion Criteria2
- Diagnosis of irritable bowel syndrome (IBS)
- Gene testing has been conducted regarding genes regulating the production of sucrase-isomaltase ensymes in previous dietary interventions using the starch- and sucrose reduced diet (SSRD) or multi-center study.
Exclusion Criteria7
- Diagnosis of inflammatory bowel disease, celiac disease, bile salt malabsorption, gastroenteritis or enteric dysmotility
- Severe food allergy
- Serious heart-, lung-, cardiovascular-, malignant- or mental illness
- Ongoing eating disorder
- Pregnancy
- Recent major gastrointestinal surgery
- Alcohol and/or drug addiction
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Interventions
Meal load during 15 minutes
Locations(1)
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NCT07309601