Digoxin After Acute Heart Failure

This study is testing whether digoxin — an older heart medication — can help people who have recently been hospitalized for heart failure with a weak pumping heart (called heart failure with reduced ejection fraction, or HFrEF). Researchers want to see if it improves exercise capacity and reduces hospital readmissions. **You may be eligible if...** - You are 18 or older - You were recently in the hospital or emergency room for a heart failure flare-up - Your heart pumps at 40% or less of its normal capacity (LVEF ≤ 40%) - Your resting heart rate is 60 beats per minute or more (if you don't have a pacemaker) - You can walk 450 meters or less in a 6-minute walk test - You have elevated blood markers indicating your heart is under strain (NT-proBNP) **You may NOT be eligible if...** - You had a recent heart attack, heart surgery, or stroke (within the past 30 days) - Your kidneys are working very poorly - You have an implanted heart pump or are on a transplant waiting list - Your BMI is 35 or higher - You have a specific type of heart disease like hypertrophic or amyloid cardiomyopathy - You have a history of serious irregular heartbeats - You have an accessory heart pathway (like Wolff-Parkinson-White syndrome) Talk to your doctor to see if this trial is right for you.