Prolonged Nasogastric Administration of Ketones in Decompensated Heart Failure
Feasibility and Safety of Prolonged Nasogastric Administration of Ketones in Decompensated Heart Failure
Institute for Clinical and Experimental Medicine
12 participants
Apr 4, 2026
INTERVENTIONAL
Conditions
Summary
This study will evaluate the feasibility and safety of achieving therapeutic concentrations of beta-hydroxybutyrate using continuous infusion of D-beta-hydroxybutyrate monoester administered via a nasogastric tube in patients with acutely decompensated heart failure with reduced left ventricular ejection fraction.
Eligibility
Inclusion Criteria2
- LVEF <35%
- Acute heart failure with low cardiac output syndrome or cardiogenic shock
Exclusion Criteria6
- Severe liver failure
- Severe acidosis
- Inability to insert nasogastric tube
- Gastric paralysis / ileus
- Repeated vomiting
- Severe hypokalemia
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Interventions
Continous infusion of a commercially available ketone monoester via nasogastric tube.
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT07527156