RecruitingNCT07321665

Effects of Physical Activity and Fitness, Cardiovascular- and Psychosocial Health on Medically Assisted Reproduction

Sponsor

University Hospital, Basel, Switzerland

Enrollment

115 participants

Start Date

Jan 16, 2026

Study Type

OBSERVATIONAL

Conditions

Infertility, Female

Summary

This prospective observational study aims to investigate the association between physical activity and clinical pregnancy rates in women undergoing medically assisted reproduction. Additionally, it evaluates how cardiorespiratory fitness, cardiovascular health, psychosocial factors, sleep quality, stress, and cognitive function relate to reproductive outcomes.

Eligibility

Sex: FEMALEMin Age: 18 YearsMax Age: 43 Years

Inclusion Criteria3

Voluntary written informed consent of the participant has been obtained prior to any screening procedures
Age 18-43
Planning to undergo MAR (eg, IUI, IVF, ICSI) - Physically able to cycle for cardiopulmonary exercise testing (CPET)

Exclusion Criteria8

Any reduction in general state of health preventing from performing hormonal stimulation for MAR
Absolute and relative contraindications for cardiopulmonary exercise testing (CPET) - No pregnancy at initial screening - Current illicit drug abuse including daily marijuana and CBD consumption (alcohol ≤2 drinks per day allowed)
Any kind of severe chronic disease (e.g. severe heart failure, active cancer disease)
Severe renal impairment (e.g. estimated glomerular filtration rate <30 ml/min/m2)
Known liver cirrhosis or other severe liver impairment
Uncontrolled dysthyroidism
Uncontrolled hypertension
Inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, etc.

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Interventions

OTHERHealth, fitness and lifestyle assessment

Participants undergo a comprehensive, non-interventional longitudinal assessment of physical activity, cardiovascular health, psychosocial factors, sleep quality, and cognitive function integrated into routine medically assisted reproduction care.