RecruitingNot ApplicableNCT07324161

Efficacy and Safety of Transcranial Magnetic Stimulation in Treatment of Alzheimer's Disease

Efficacy and Safety of Repetitive Transcranial Magnetic Stimulation in the Treatment of Alzheimer's Disease and Exploration of Glymphatic Mechanisms

Sponsor

Fujian Medical University Union Hospital

Enrollment

66 participants

Start Date

Apr 16, 2025

Study Type

INTERVENTIONAL

Conditions

Alzheimer s Disease

Summary

This study is grounded in the regulatory mechanisms of the glymphatic system and applies repetitive transcranial magnetic stimulation (rTMS) to the treatment of Alzheimer's disease (AD). The clinical efficacy and safety of rTMS will be systematically evaluated. Furthermore, transcranial magnetic stimulation-evoked potentials (TMS-EEG) and functional near-infrared spectroscopy (fNIRS) will be employed to investigate, from the perspectives of synaptic plasticity and neurovascular coupling, the mechanisms by which rTMS influences glymphatic function. Collectively, this work aims to provide new insights into both the therapeutic effectiveness and the underlying mechanisms of rTMS in AD.

Eligibility

Min Age: 50 YearsMax Age: 90 Years

Plain Language Summary

Simplified for easier understanding

This study is testing transcranial magnetic stimulation (TMS) — a non-invasive brain stimulation technique using magnetic pulses — to see if it can improve thinking, memory, and daily functioning in people with Alzheimer's disease. **You may be eligible if...** - You have been diagnosed with Alzheimer's disease (mild to moderate stage, CDR score 1–2) - Brain tests (amyloid PET scan, spinal fluid, or blood biomarkers) confirm the presence of Alzheimer's disease changes - You meet the 2018 diagnostic criteria for Alzheimer's disease **You may NOT be eligible if...** - You have a metal implant or medical device that makes TMS unsafe (like a pacemaker) - You have epilepsy - You have a serious immune condition or other severe complication - You are unable to cooperate with study procedures Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICErTMS

Stimulation coil Cool-B65 A CO, positioning individualised, stimulation frequency 20Hz, stimulation intensity 100% of motor threshold, stimulation number 40 pulses/train, train interval 28s, 40 trains, 1600 total stimulation pulses, total stimulation time 20 min, treatment application once a day, continuous application for two weeks, 5 days a week.Consolidation therapy was also administered weekly for 6 months.

DEVICEsham rTMS

Stimulation coil Cool-B65 P CO, positioning individualised, stimulation frequency 20Hz, stimulation intensity 100% of motor threshold, stimulation number 40 pulses/train, train interval 28s, 40 trains, 1600 total stimulation pulses, total stimulation time 20 min, treatment application once a day, continuous application for two weeks, 5 days a week

Locations(1)

rTMS

Fuzhou, Fujian, China

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NCT07324161

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