Impact of a Multicomponent Exercise Program on Cognitive and Functional Outcomes in Patients With Mild Cognitive Impairment
Effectiveness of an Innovative Therapeutic Exercise Program on Physical and Cognitive Function in Mild Cognitive Impairment Due to Alzheimer's Disease
University of Patras
45 participants
Dec 1, 2025
INTERVENTIONAL
Conditions
Summary
The goal of this randomised clinical trial is to investigate the effectiveness of an innovative therapeutic exercise program emphasizing in dual-task exercises in people with amnestic Mild Cognitive Impairment. The main questions it aims to answer are: Does the innovative therapeutic exercise program improve gait and balance? Does the innovative therapeutic exercise program improve cognition? Researchers will compare the innovative therapeutic exercise program emphasizing in dual-task exercises to a therapeutic exercise program without emphasizing in dual-task exercises and to a control group (given instruction about the benefits of exercise). Participants will: * Perform the exercise program twice a week for three months. * Will be assessed before and after the intervention. * Will record The Borg Scale of Perceived Exertion every second week to monitor and assess the progression of exercise intensity.
Eligibility
Inclusion Criteria4
- individuals \> 50 years old
- people with confirmed cognitive impairment, as evidenced by values within normal limits on the Montreal Cognitive Assessment test (MOCA ) \>20
- stable medication in the last month
- independent walking
Exclusion Criteria6
- people with dementia
- people suffering from chronic mental illness (e.g. schizophrenia, bipolar disorder)
- people suffering from a neurological disorder or injuries (e.g. multiple sclerosis, Parkinson's, traumatic brain injury)
- people with clinical depression (as determined by the Neuropsychiatric Inventory (NPI) assessment and medical diagnosis)
- people who have had recent surgery
- people with insufficient knowledge of the Greek language
Interventions
Aerobic, strengthening and balance exercises combined with cognitive training -name: Experimental group 1 (EXP1)
Aerobic, strengthening and balance exercises without cognitive training- name: Experimental group 2 (EXP2)
The control group will receive only educational material in the form of a flyer, outlining the importance and potential benefits of physical activity, along with general lifestyle recommendations, without participating in the structured exercise intervention- name: Control group (CG)
Locations(1)
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NCT07334392