RecruitingNCT07343336

Landscape of Gout in French Polynesia.

FENUA-METABOGOUT : Genetic Landscape of Gout, Inflammation and Metabolic Diseases in French Polynesia.

Sponsor

Lille Catholic University

Enrollment

2,750 participants

Start Date

Sep 2, 2025

Study Type

OBSERVATIONAL

Conditions

Inflammation Metabolic Diseases Gout Disease

Summary

The aim of this research is to characterise the genetic and molecular landscape of gout, inflammation and metabolic diseases, as well as the associated molecular, anthropomorphic and pathological characteristics.

Eligibility

Min Age: 18 YearsMax Age: 75 Years

Inclusion Criteria20

All participants:
Age between 18 and 75 years old inclusive
Signature of informed consent
Fasting for the collection of biological samples
Declared Polynesian ancestry
Affiliated to a social security scheme
General population group :
Not having participated to the 2021 TOPATA study
Visiting a general practitioner (for whatever reason)
Gout Group :
Managed at the rheumatology clinic of the Taaone Hospital Centre (CHT) in Papeete by Dr Baptiste Gérard.
Tophaceous gout sub-group:
Present with tophaceous gout.
Gout crisis subgroup:
Be within 48 hours of the onset of a gout attack
Agree to return 1 week after inclusion for the second blood and urine sample.
follow-up group:
To have been included in the TOPATA study in 2021
Have taken the genetic and biological samples that generated the genetic and serum urate data for the 2021 study
Have hyperuricaemia without signs of gout OR without hyperuricaemia or gout at the time of inclusion in TOPATA

Exclusion Criteria12

All participants :
Refusal or inability to understand or give consent
Physical inability to follow and respect the protocol
st degree relative\*,
Person under guardianship or trusteeship
Pregnant or breast-feeding woman
\* If several relatives from the same household are eligible to participate, only one person may be included in the study. The choice is left to the discretion of the investigator or the first person met. However, both members of a couple (e.g. husband and wife) may participate.
General population group :
Unable to return for sampling if required.
Gout group :
Person wearing a knee prosthesis
People suffering from other inflammatory rheumatic diseases

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Interventions

OTHEREpidemiological study

Collection of sociodemographic data, collection of treatment data, standard and clinical ophthalmological examination, physical and biological measurements, clinical characteristics specific to chronic and metabolic diseases, questionnaires (gout questionnaire, health assessment questionnaire (HAQ-II), EuroQol (EQ)-5D-5L, joint pain, state of health, diet and physical activity, access to care, addictions, sleep quality, pain scale (EVA), personal and family history) will be performed.

DIAGNOSTIC_TESTBlood and urine tests

Collection of blood and urine samples for genetic, biochemical, omics, and biobank analyses, in order to characterize cardiometabolic health markers will be performed.