RecruitingNot ApplicableNCT07344467

Oral Melatonin Versus Oral Pregabalin on Postoperative Pain and Anxiety Following Spine Surgery

Effect of Oral Melatonin Versus Oral Pregabalin on Postoperative Pain and Anxiety Following Spine Surgery: A Prospective, Randomized Controlled Trial

Sponsor

Tanta University

Enrollment

105 participants

Start Date

Jan 17, 2026

Study Type

INTERVENTIONAL

Conditions

Postoperative Pain Anxiety Oral Melatonin Pregabalin Spine Surgery

Summary

This study aims to compare the efficacy of using Melatonin versus Pregabalin on postoperative pain and anxiety after spine surgeries.

Eligibility

Min Age: 21 YearsMax Age: 60 Years

Plain Language Summary

Simplified for easier understanding

This study is comparing two medications — melatonin and pregabalin — given by mouth before spine surgery to see which one better reduces pain and anxiety after the operation. **You may be eligible if...** - You are 21–60 years old (male or female) - You are scheduled for planned (elective) spine surgery - You are generally healthy or have only mild health conditions (ASA I or II) **You may NOT be eligible if...** - You are allergic to melatonin or pregabalin - You have heart disease, kidney disease, or liver disease - You have a psychological disorder, dementia, or severe depression - You have a circadian rhythm disorder (e.g., chronic fatigue syndrome) - You refuse to participate Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERPlacebo capsule

Patients will be receive one oral placebo capsule the evening before surgery, one oral placebo capsule 2 hours prior to surgery, and one oral placebo capsule in the morning and one in the evening for 3 consecutive days postoperatively.

DRUGMelatonin capsule

Participants will receive one 5 mg oral melatonin capsule the evening before surgery, one 5 mg oral melatonin capsule 2 hours prior to surgery, and one oral placebo capsule in the morning, and one 5 mg oral melatonin capsule in the evening, daily for 3 consecutive days postoperatively.

DRUGPregabalin capsule

Participants will receive one 75 mg oral pregabalin capsule the evening before surgery, one 75 mg oral pregabalin capsule 2 hours prior to surgery, and one 75 mg oral pregabalin capsule in the morning, and another in the evening, daily for 3 consecutive days postoperatively.