miR-342-5p/AnkG Pathway in Early AD Synaptic Dysfunction

This study is investigating a specific biological pathway — miR-342-5p and AnkG — that researchers believe plays a role in early nerve damage and memory loss in Alzheimer's disease. The study compares brain biomarkers in people with Alzheimer's to those in healthy people of the same age to better understand the earliest stages of the disease. **You may be eligible if:** - You are 50 years or older - You have been diagnosed with probable Alzheimer's disease based on established clinical criteria - Your brain MRI shows typical Alzheimer's patterns (shrinkage in the hippocampus and temporal lobes) - Your cognitive test scores fall within the defined range for Alzheimer's dementia - OR you are a healthy adult with no memory problems, no family history of dementia, and normal brain imaging (for the control group) **You may NOT be eligible if:** - Your memory problems are caused by a different condition - You have a history of drug or alcohol abuse - You have had a significant head injury - You have depression, schizophrenia, or serious heart, liver, kidney, or blood disorders - You are unable to cooperate or communicate Talk to your doctor to see if this trial is right for you.