RecruitingNot ApplicableNCT07363941

HEIGHT-BASED AND CONVENTIONAL SPINAL ANAESTHETIC DOSING IN GERIATRIC PATIENTS

COMPARISON OF HEMODYNAMIC AND ANAESTHETIC OUTCOMES BETWEEN HEIGHT-BASED AND CONVENTIONAL SPINAL ANAESTHETIC DOSING IN GERIATRIC PATIENTS UNDERGOING LOWER LIMB ORTHOPAEDIC SURGERIES

Sponsor

Shaheed Mohtarma Benazir Bhutto Institue of Trauma

Enrollment

104 participants

Start Date

Jan 3, 2026

Study Type

INTERVENTIONAL

Conditions

Spinal Anesthesia Induced Hypotension Geriatric Population Spinal Anesthesia in Elderly Patients

Summary

The goal of this clinical trial is to find out whether height-based dosing of spinal anaesthesia provides better hemodynamic stability and anesthetic outcome than conventional fixed dosing in elderly patients undergoing lower limb orthopaedic surgery.The main questions this study aims to answer are: 1. Does height-based spinal anaesthetic dosing reduce the risk of hypotension and bradycardia during surgery as compared to conventional fixed dosing? 2. Does it improve anaesthetic outcomes, such as the onset and duration of sensory and motor block?

Eligibility

Min Age: 60 YearsMax Age: 80 Years

Inclusion Criteria3

Individuals aged 60 to 80 years. Either gender (male or female). Patients who are ASA physical status I-III. Individuals scheduled to undergo elective lower limb orthopaedic surgeries (e.g., fracture fixation, total knee replacement, open reduction and internal fixation).
Patients planned to receive spinal anaesthesia as the primary anaesthetic technique.
Those who provide informed written consent for participation in the study.

Exclusion Criteria6

Individuals exhibiting a stature inferior to 150 cm. Patients receiving anti-hypertensive drugs or those on beta blockers or beta-agonists.
Patients with a history of neurological disease like CVA or Parkinsonism. Patients presenting with sepsis (≥ 2 positive SIRS criteria with positive aseptically obtained blood or wound culture).
Patients with a history of coagulation disorders like haemophilia or vWD or those with a history of anti-platelet drug intake in the last 2 weeks.
Individuals possessing a documented history of hypersensitivity reactions to pharmacological agents utilized in the research.
Patients who will be diagnosed with a skin infection at the spinal needle puncture site.
Patients undergoing emergency orthopaedic procedures requiring immediate intervention

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Interventions

DRUGGroup A : Spinal Anaesthetic Dose

Participants will receive 0.07 mg/cm of 0.5% Hyperbaric Bupivacaine in conjunction with 2 mg (0.5 ml) of preservative-free Dexamethasone administered intrathecally

DRUGGroup B : Conventional Dose

Participants will receive 12.5 mg (2.5 ml) of 0.5% Hyperbaric Bupivacaine alongside 2 mg (0.5 ml) of preservative-free Dexamethasone intrathecally