RecruitingNCT07376278

Predictors of Clinical Outcomes of Deep Brain Stimulation in Parkinson's Disease

A Prospective Observational Study for the Predictors of Clinical Outcomes of Deep Brain Stimulation in Parkinson's Disease

Sponsor

Hong Kong University of Science and Technology

Enrollment

30 participants

Start Date

Feb 5, 2026

Study Type

OBSERVATIONAL

Conditions

Deep Brain Stimulation PARKINSON DISEASE (Disorder)

Summary

The goal of this observational study is to identify factors in blood that are associated with response to deep brain stimulation (DBS) surgery in patients with Parkinson's disease. The main questions it aims to answer are: 1. What factors in blood (proteins and RNA) are associated with good vs poor response to DBS? 2. Are these factors able to predict response to DBS? 3. How do these factors change before and after DBS? Blood and leftover brain tissue (which spontaneously adhere to the surgical instruments) will be taken and routine clinical data (including scores from routine assessments) will be collected from consenting participants who undergo DBS.

Eligibility

Min Age: 18 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This study aims to identify which factors — such as brain scans, blood tests, or clinical features — best predict how well patients with Parkinson's disease will respond to deep brain stimulation (DBS), a surgical procedure that uses electrical impulses to improve movement symptoms. **You may be eligible if...** - You have a confirmed Parkinson's disease diagnosis - You have significant movement problems despite being on optimal medication - Your symptoms improve substantially when you take levodopa (a Parkinson's medication) - You are 75 years old or younger - You have been referred for DBS surgery under standard clinical guidelines **You may NOT be eligible if...** - You are unwilling to provide blood samples for the study - Your Parkinson's symptoms are caused by heavy metal exposure - You have other neurological conditions, brain infections, MS, HIV, or recent cancer - You are unable to pass the pre-surgical DBS assessment or are unwilling to undergo the surgery Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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