RecruitingNot ApplicableNCT07383220

Effect of Electrical Stimulation and Exercise on Blood Flow in Patients With Resistant High Blood Pressure

Effect of Combined Transcutaneous Electrical Stimulation and Isometric Exercise on Peripheral Hemodynamic Parameters in Patients With Resistant Hypertension

Sponsor

Mohamed Mohamed Ali Morgan

Enrollment

50 participants

Start Date

Jan 15, 2026

Study Type

INTERVENTIONAL

Conditions

Metabolic Syndrome Abdominal Obesity High Blood Pressure Hypertension (HTN)Hemodynamic Instability Resistant Hypertension Essential (Primary) Hypertension Vascular Resistance

Summary

The goal of this clinical trial is to learn if the combination between transcutaneous electrical nerve stimulation (TENS) and isometric exercise (IE) can improve blood pressure in men and women between 50 to 60 years old suffered from resistant hypertension which is a type of hypertension where blood pressure remains above your target goal despite the use of three or more different classes of antihypertensive medications at their maximum tolerated doses. The main question to answer is: Is there a significant effect on the combined use of TENS and IE on peripheral hemodynamic parameters in patients with resistant hypertension? Total sample will be 50 patients from both sexes I will compare between two groups: Experimental group (15 men, 10 women) will take: medication plus IE and TENS Control group (15 men, 10 women) will take: medication plus Conventional Physical Therapy Program

Eligibility

Min Age: 50 YearsMax Age: 60 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a combination of electrical nerve stimulation (a device that sends gentle electrical pulses through the skin) and exercise to improve blood flow in people with treatment-resistant high blood pressure — meaning blood pressure that remains high even when taking three or more medications. **You may be eligible if...** - You are between 50 and 60 years old - You have had high blood pressure for at least 5 years - Your blood pressure is still high despite taking three or more different blood pressure medications - You have a BMI between 25 and 34.9 (overweight range) - You have an increased waist circumference (over 102 cm for men, over 88 cm for women) **You may NOT be eligible if...** - Your high blood pressure is caused by an identifiable condition (e.g., a kidney or adrenal problem) - You had a heart attack, stroke, or heart failure episode in the last 6 months - You have a serious joint, muscle, or nerve condition that prevents safe exercise - You have a pacemaker or implanted heart device (not compatible with electrical stimulation) - You have uncontrolled heart rhythm problems, open skin wounds, or significant nerve damage in the skin - You have cognitive or psychiatric issues that would interfere with participation Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICETranscutaneous Electrical Nerve Stimulation

Application of TENS Electrode placements: bilaterally over the Paraspinal muscles at the T1-T5 levels (upper thoracic region), targeting sympathetic outflow to the cardiovascular system. Frequency: 2-10 Hz (low frequency stimulation) Pulse duration: 200 microseconds Intensity: strong but comfortable tingling sensations, below motor threshold (typically between 10-20mA) Session duration: 30 minutes per session Session frequency: 3 times per week Total intervention duration: 8 weeks

BEHAVIORALIsometric Exercise

Device: Hand grip dynamometer. protocol: * 30% of the participants' maximal voluntary contraction (MVC). * Duration per trial: 2 minutes. * Number of trials per session: 4 repetitions * Rest interval between trials: 1 minute * Session frequency: 3 sessions per week * Total session duration: 14 minutes Per session: * 4 sets × 2 minutes = 8 minutes of active contraction * Rest between sets: 1 to 3 minutes (average 2 min × 3 rests = 6 minutes) * So total session time: average 14 minutes. • Total intervention duration: 8 weeks

BEHAVIORALAerobic, Dynamic Resistance, stretch and Breathing Exercises and Lifestyle Modification Advices

1. Aerobic exercise: moderate (brisk walking): 30 min, 5 times per week. 2. Engage in dynamic resistance exercise (weight training): 2 or more days non-consecutive. 3. Minimize sedentary behavior 4. Maintain healthy weight 5. Nutritional advice like: * Eat at least 5 portions of fruit and vegetables * Eat more lean protein e.g. Fish and nuts * Eat less salt \<5g or 1tsp * Eat 25-29 g of fiber * Limit alcohol * Drink 2-3 cups of coffee and/or tea (unsweetened) 6. Others: * Sleep: 7-9h/day * Reduce stress: practice meditation or yoga 30 min per day * Listen to music at least 25 min, 3 times per week * Stop smoking * Limit pollutions exposure * Use digital wearables/apps to track movement 7. Breathing exercise: Slow breathing at a rate of 6 breath/min for 10 minutes. 8. Stretching exercise: Static stretching exercise is mainly for large bulky muscles 30 sec stretch, 30 sec rest for 5 min