RecruitingNot ApplicableNCT07401888

A Study Of Milk Consumption In Metabolic Syndrome

Milk Consumption On Cardiovascular Risk Factors In Metabolic Syndrome


Sponsor

Mayo Clinic

Enrollment

40 participants

Start Date

Apr 13, 2026

Study Type

INTERVENTIONAL

Conditions

Summary

The primary purpose of this study is to determine the impact of whole-fat dairy consumption on cardiovascular and metabolic risk factors and peripheral vascular function in adults with metabolic syndrome.


Eligibility

Min Age: 18 YearsMax Age: 70 Years

Inclusion Criteria5

  • fasting plasma glucose ≥100 mg/dL (or medical therapy for elevated glucose)
  • HDL-C <40 mg/dL in men or <50 mg/dL in women (or medical therapy for reduced HDL-C)
  • Triglycerides ≥150 mg/dL (or medical therapy for elevated triglycerides)
  • Waist circumference >102 cm for men and >88 cm for women
  • Systolic blood pressure ≥130 mmHg or diastolic blood pressure ≥80 mmHg (or medical therapy for hypertension)

Exclusion Criteria11

  • Cardiovascular disease diagnosis
  • Type 1 or 2 diabetes diagnosis
  • Dairy allergy or lactose intolerance
  • Self-reported high baseline dairy intake (>3 servings per day)
  • >3 hours of physical activity per week
  • Pregnant women
  • Inflammatory bowel disease
  • Chronic steroid use
  • Allergy to metal
  • GLP-1 agonist use
  • Patients on medications related to metabolic syndrome where dose adjustments are planned to be made during the study period.

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Interventions

OTHERFull-fat diet

The patients will follow a full-fat, isoenergetic diet consisting of 45% carbohydrates, 20% protein, and 35% fat for a duration of three weeks.

OTHERLow-fat diet

The patients will follow a low-fat, isoenergetic diet consisting of 45% carbohydrates, 20% protein, and 35% fat for a duration of three weeks.


Locations(1)

Mayo Clinic in Rochester

Rochester, Minnesota, United States

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NCT07401888


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