RecruitingNot ApplicableNCT07424781

Fluoxetine on Emotional Experience (FLEX) Study

The Effect of Fluoxetine Treatment on Anger Processing in Healthy Young People

Sponsor

University of Oxford

Enrollment

80 participants

Start Date

Oct 1, 2025

Study Type

INTERVENTIONAL

Conditions

Depression Depression - Major Depressive Disorder Irritability

Summary

The goal of this clinical medicine study is to investigate how does antidepressant fluoxetine modulate anger processing in healthy young people . The main questions it aims is to answer are: 1. How does fluoxetine affect responses to anger-related stimuli such as words, faces, and autobiographical recall? 2. How does fluoxetine influence responses during frustration induction in frustrative non-reward and threat paradigms? 3. Does the effect manifest in physiological markers, including heart rate variability and facial expressions? Researchers will compare fluoxetine to a placebo to see if drug fluoxetine affects anger processing. Participants will: Take 20mg fluoxetine or a placebo every day for 7 days. Visit the university site for questionnaire and tasks assessments. Heart rate variability and facial expressions will be recorded in some of the tasks.

Eligibility

Min Age: 18 YearsMax Age: 24 Years

Plain Language Summary

Simplified for easier understanding

This study — called the FLEX study — is examining how a common antidepressant called fluoxetine (Prozac) affects emotional experiences and feelings in young healthy adults. This is a research study about how the drug influences emotions, not a treatment trial for depression. **You may be eligible if...** - You are between 18 and 24 years old - You live in the UK for the duration of the study - You have normal or corrected vision - You speak English fluently enough to complete the study tasks **You may NOT be eligible if...** - You have a current or past psychiatric diagnosis (including depression, anxiety disorders, personality disorders, or substance dependency) - You have a first-degree family member with a diagnosis of mania - You have other health conditions that would interfere with participation Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGFluoxetine

Participants will receive 20mg of fluoxetine daily for 7 days. Tablets encapsulated to aid blinding.

DRUGPlacebo

Participants will receive one dose placebo (sucrose) daily for 7 days. Tablets encapsulated to aid blinding.

Locations(1)

Department of Psychiatry, University of Oxford

Oxford, Oxfordshire, United Kingdom

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NCT07424781

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