Cryoneurolysis Prior to Total Knee Arthroplasty (CRYO-TKA Trial)
Association of Pre-operative Genicular Nerves Cryoneurolysis With Improved Pain and Function in Patients Undergoing Total Knee Arthroplasty
Attikon Hospital
100 participants
Jan 2, 2026
INTERVENTIONAL
Conditions
Summary
Approximately 20-30% of patients experience persistent pain after a Total Knee Arthroplasty (TKA). This study investigates whether percutaneous cryoneurolysis of genicular nerves can reduce pain and improve physical function when performed at least 24 hours before surgery. Participants will be randomized to receive either the cryoneurolysis procedure + TKA or TKA only. Results will be tracked for 6 months to see if the intervention improves long-term recovery and quality of life.
Eligibility
Inclusion Criteria3
- Adults ≥18 years undergoing primary TKA for osteoarthritis.
- Cognitively normal and able to self-assess pain and function.
- Provide written informed consent.
Exclusion Criteria3
- Cancer-related knee pain.
- Neurological, psychiatric, or medical conditions interfering with assessment.
- Chronic opioid users.
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Interventions
Percutaneous CT-guided cryoneurolysis using up to three cryoprobes (-20°C to -100°C) for temporary sensory nerve interruption.
Locations(1)
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NCT07425457