arthroplasty Clinical Trials

5 recruitingLast updated: May 5, 2026

There are 189 actively recruiting arthroplasty clinical trials across 33 countries. Studies span Not Applicable, Phase 4, Phase 2, Phase 3, Phase 1. Top locations include New York, New York, United States, Paris, France, Lyon, France. Updated daily from ClinicalTrials.gov.


arthroplasty Trials at a Glance

189 actively recruiting trials for arthroplasty are listed on ClinicalTrialsFinder across 6 cities in 33 countries. The largest study group is Not Applicable with 102 trials, with the heaviest enrollment activity in New York, Paris, and Lyon. Lead sponsors running arthroplasty studies include Medacta International SA, Hospital for Special Surgery, New York, and Hospices Civils de Lyon.

Browse arthroplasty trials by phase

Treatments under study

About arthroplasty Clinical Trials

Looking for clinical trials for arthroplasty? There are currently 5 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new arthroplasty trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about arthroplasty clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 189 trials

Recruiting

Prospective Follow-up of the Prevision Hip Stem With Comparison of Different Implant Variants

Revision Total Hip ArthroplastyPeriprosthetic Fracture of Hip
Aesculap AG120 enrolled2 locationsNCT06626490
Recruiting
Not Applicable

Binaural Beats for Postoperative Pain and Anxiety Reduction

AnxietyTotal Hip Arthroplasty (THA)Total Knee Replacement+6 more
University of Miami50 enrolled1 locationNCT07437469
Recruiting
Not Applicable

Comparing ACB+IPACK and ACB+BiFeS Block Combinations for Analgesia in Total Knee Arthroplasty

Postoperative PainTotal Knee Arthroplasty
Hitit University78 enrolled1 locationNCT07561333
Recruiting
Not Applicable

CLinical Evaluation of ANtiseptic Skin Preparation in Revision Total Joint Arthroplasty of the Hip and Knee

Revision Total Hip Arthroplasty (RTHA)Revision Total Knee Arthroplasty
Sunnybrook Health Sciences Centre400 enrolled3 locationsNCT05828810
Recruiting

Ambispective Multicentric Study Evaluating UKA With U-Knee/Uni-Kroma Implants

Unicompartmental Knee Arthroplasty
Societe dEtude, de Recherche et de Fabrication400 enrolled1 locationNCT05876143
Recruiting
Not Applicable

BiFeS vs. iPACK in Postoperative Knee Arthroplasty Analgesia

Pain, PostoperativeArthroplasty Replacement, KneeAnesthesia Regional
Amasya University88 enrolled1 locationNCT07360392
Recruiting
Not Applicable

Does Joint Immobilization Following Revision Total Knee Arthroplasty Improve Range of Motion Following Surgery?

Aseptic Revision Knee ArthroplastyStiffness Following Revision Knee Arthroplasty
Hospital for Special Surgery, New York170 enrolled1 locationNCT07552415
Recruiting
Not Applicable

Early Rehabilitation After Total Hip Arthroplasty

Total Hip Arthroplasty (THA)
Muğla Sıtkı Koçman University52 enrolled1 locationNCT07550647
Recruiting
Not Applicable

Analgesic Efficacy of Quadro-Iliac Plane Block Versus Erector Spinae Plane in Total Hip Arthroplasty

Total Hip ArthroplastyErector Spinae Plane BlockAnalgesic Efficacy+1 more
Tanta University76 enrolled1 locationNCT07537036
Recruiting
Phase 2

Efficacy and Safety of TRD205 Tablets for Postoperative Analgesia in Unilateral Total Hip Arthroplasty (Phase IIb)

Postoperative Analgesia After Unilateral Hip Arthroplasty
Beijing Tide Pharmaceutical Co., Ltd200 enrolled1 locationNCT07543796
Recruiting
Not Applicable

Femoral Triangle Block vs Adductor Canal Block on Early Quadriceps Function After Total Knee Arthroplasty

Total Knee ArthroplastyTotal Knee Arthroplasty RecoveryTotal Knee Arthroplasty (Postoperative Pain)
Social Medical Corporation Daiyukai136 enrolled1 locationNCT07524387
Recruiting
Phase 1

Methylene Blue in Total Knee Arthroplasty (TKA)

Total Knee Arthroplasty
University of Miami20 enrolled1 locationNCT07324954
Recruiting
Phase 4

Medrol Dosepak for Outpatient Total Knee Arthroplasty

Total Knee Arthroplasty
Rush University Medical Center420 enrolled1 locationNCT05097976
Recruiting

Clinical Performance of XPEO-E Liner in SERF Dual-mobility Cups

Total Hip Arthroplasty (THA)
Societe dEtude, de Recherche et de Fabrication500 enrolled5 locationsNCT06917365
Recruiting
Not Applicable

A Prospective, Randomized, Single-blind, Controlled, Multi-center Study to Assess the Safety and Performance of MagnetOsTM Compared to Autogenous Bone Graft in Patients Undergoing Hindfoot or Ankle Fusions.

Ankle DiseaseAnkle Arthrodesis or ArthroplastyHindfoot Fusion+3 more
Kuros Biosurgery AG126 enrolled5 locationsNCT07225751
Recruiting

Comparison of the Analgesic Efficacy of Adductor Canal Block and Combined Adductor Canal Block Plus IPACK Block in Knee Surgery

Knee Arthroplasty, Total
TC Erciyes University60 enrolled2 locationsNCT07526831
Recruiting
Not Applicable

Are Elastic Restraints Still Necessary in Improved Rehabilitation Programs After Hip and Knee Prosthetic Surgery?

Arthroplasty Complications
Clinique Pasteur Lanroze1,274 enrolled1 locationNCT06563531
Recruiting
Not Applicable

Development of an Outcome Score for Patients With Knee Osteoarthritis and Knee Joint Endoprosthesis Using an App

Hip ArthroplastyKnee OsteoarthritisKnee Arthroplasty+1 more
Technical University of Munich1,250 enrolled1 locationNCT07212699
Recruiting
Not Applicable

Innovating Physical Therapy: A Pilot Study on Band Connect's Impact on Compliance, Satisfaction, and Revenue

Rotator Cuff TearsReverse Total Shoulder ArthroplastyAnatomic Total Shoulder Arthroplasty
University Hospitals Cleveland Medical Center499 enrolled1 locationNCT06733480
Recruiting

Characteristics of Persistent Pain Composition Following Total Hip or Knee Arthroplasty: a Descriptive Study

Survey and QuestionnairePain (Visceral, Somatic, or Neuropathic)Hip Arthroplasty Replacement+1 more
Rigshospitalet, Denmark100 enrolled1 locationNCT07110324