arthroplasty Clinical Trials

227 recruitingLast updated: June 20, 2026

There are 227 actively recruiting arthroplasty clinical trials across 35 countries. Studies span Not Applicable, Phase 4, Phase 2, Phase 3, Phase 1. Top locations include New York, New York, United States, Paris, France, Chicago, Illinois, United States. Updated daily from ClinicalTrials.gov.


arthroplasty Trials at a Glance

227 actively recruiting trials for arthroplasty are listed on ClinicalTrialsFinder across 6 cities in 35 countries. The largest study group is Not Applicable with 122 trials, with the heaviest enrollment activity in New York, Paris, and Chicago. Lead sponsors running arthroplasty studies include Medacta International SA, Hospital for Special Surgery, New York, and Tanta University.

Browse arthroplasty trials by phase

Treatments under study

About arthroplasty Clinical Trials

Looking for clinical trials for arthroplasty? There are currently 9 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new arthroplasty trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about arthroplasty clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 227 trials

Recruiting
Not Applicable

Wound Healing, Dressing Type, and Dressing Change Frequency in THA

Total Hip Arthroplasty (THA)Wound Healing Time
Clinical Center of Vojvodina90 enrolled1 locationNCT07655388
Recruiting
Not Applicable

Preoperative Fasting and the Gut Microbiome Before Hip Replacement

Surgical wound infectionPostoperative ComplicationsGastrointestinal Microbiome+2 more
Charite University, Berlin, Germany130 enrolled1 locationNCT07651462
Recruiting
Not Applicable

PENG Block + LIA For Endoprosthesis Surgery

anesthesia and analgesiaPain, PostoperativeNerve Block+3 more
ASST Gaetano Pini-CTO100 enrolled1 locationNCT07239817
Recruiting

Heidelberg Registry for Hip and Knee Joint Implants and Revisions

arthroplastyOsteoarthritis
University Hospital Heidelberg10,000 enrolled1 locationNCT06850818
Recruiting

Post-Market Clinical Follow-Up (PMCF) Study Evaluating the Safety and Efficacy of Tıpmed™ Primary Hip Prosthesis System

Osteoarthritis (OA) of the hipTotal Hip Arthroplasty (THA)Joint Diseases+2 more
TIPMED Medical Device Manufacturing Ltd. Co.101 enrolled4 locationsNCT07651735
Recruiting
Not Applicable

Biceps Femoris Short Head (BiFeS) Block and Adductor Canal Block for Postoperative Analgesia Following Total Knee Arthroplasty

Total Knee ArthroplastyPostoperative Pain Following Knee Arthroplasty
Ömer Kayar60 enrolled1 locationNCT07577869
Recruiting
Not Applicable

Early Versus Delayed Rehabilitation After Reverse Total Shoulder Arthroplasty for Proximal Humerus Fracture

Orthopedic DisorderHumerus fractureSHOULDER ARTHROPLASTY+1 more
University of Virginia10 enrolled1 locationNCT06869343
Recruiting
Not Applicable

Effects of Progressive Restricted Blood Flow Exercises in Post Total Knee Arthroplasty

Total Knee Arthroplasty Recovery
Lahore University of Biological and Applied Sciences48 enrolled1 locationNCT07601906
Recruiting
Not Applicable

INHANCE Stemless Reverse Shoulder IDE

arthroplastyShoulderReplacement
DePuy Orthopaedics168 enrolled19 locationsNCT06323980
Recruiting
Phase 4

Branched Chain Amino Acids for Sarcopenia in Patients Undergoing Total Knee Arthroplasty

SarcopeniaTotal Knee Arthroplasty
Seoul National University Hospital140 enrolled3 locationsNCT07634523
Recruiting

The Relationship Between Preoperative Anxiety Level and Frailty Score in Elderly Patients Scheduled for Elective Hip Arthroplasty: A Prospective Observational Study

Hip ArthroplastyAnxiety PreoperativeFraility
Başakşehir Çam & Sakura City Hospital142 enrolled1 locationNCT07633483
Recruiting
Not Applicable

Infiltration or Nerve Blocks in Addition to Adductor Canal Block

gonarthrosisTotal Knee Arthroplasty
GCS Ramsay Santé pour l'Enseignement et la Recherche100 enrolled2 locationsNCT06920186
Recruiting
Phase 3

Suzetrigine in Total Hip Arthroplasty

Total Hip Replacement SurgeryPainPain Management+13 more
Hospital for Special Surgery, New York210 enrolled1 locationNCT07226700
Recruiting
Phase 4

Flex Appeal: Evaluating the Efficacy of Anesthetic Techniques for Manipulation of Knees Under Anesthesia

Knee Stiffness After Total Knee Arthroplasty
Duke University128 enrolled1 locationNCT07348614
Recruiting
Not Applicable

Cryotherapy Versus Standard Care in Reducing Opioid Consumption After Total Knee Arthroplasty

Postoperative PainOsteoarthritis, KneeTotal Knee Arthroplasty
Hospital Italiano de Buenos Aires74 enrolled1 locationNCT07630337
Recruiting
Phase 4

Vancomycin in TKAs

Total Knee Arthroplasty
University of California, San Diego30 enrolled1 locationNCT07282782
Recruiting
Not Applicable

Persona MC vs PS RCT With ROSA

Total Knee Arthroplasty
NYU Langone Health200 enrolled1 locationNCT05391828
Recruiting
Not Applicable

Supra-Iliac Anterior Quadratus Lumborum Block and Pericapsular Nerve Group (PENG) Block for Analgesia After Total Hip Arthroplasty

AnalgesiaTotal Hip ArthroplastyPericapsular Nerve Group Block+1 more
Tanta University50 enrolled1 locationNCT07606794
Recruiting

Oral vs Intravenous Dexamethasone in Total Knee Arthroplasty

Knee OsteoarthritisTotal Knee ArthroplastyGonarthrosis; Primary
Haseki Training and Research Hospital270 enrolled1 locationNCT07442812
Recruiting

The Quadro-Iliac Plane (QIP) Block in Hip Arthroplasty

Hip ArthroplastyHip surgery
San Giovanni di Dio Hospital80 enrolled2 locationsNCT07591311