RecruitingPhase 4NCT07426484

Cosibelimab for CSCC in Patients With Kidney Transplant or Hematologic Malignancy

A Phase IV Master Protocol of Cosibelimab in Special Populations With Advanced Cutaneous Squamous Cell Carcinoma (CosiMaster)


Sponsor

Dana-Farber Cancer Institute

Enrollment

80 participants

Start Date

Apr 23, 2026

Study Type

INTERVENTIONAL

Conditions

Summary

This is study is to evaluate the safety and efficacy of cosibelimab in special populations with advanced cutaneous squamous cell carcinoma (CSCC). The name of the drug involved in this research study is: -cosibelimab (a type of an anti-PD-L1 antibody)


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called Cosibelimab, a drug called Everolimus, and others for people with cutaneous squamous cell carcinoma and skin cancer. The study is currently recruiting participants at 2 locations.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGCosibelimab

Anti-PD-L1 antibody, single dose vials, via intravenous (into the vein) infusion per protocol

DRUGPrednisone

Corticosteroid, per standard of care

DRUGSirolimus

mTOR Inhibitor, per standard of care

DRUGEverolimus

mTOR Inhibitor, per standard of care


Locations(2)

Brigham and Women's Hospital

Boston, Massachusetts, United States

Dana-Farber Cancer Institute

Boston, Massachusetts, United States

View Full Details on ClinicalTrials.gov

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NCT07426484


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