Skin Cancer Clinical Trials

99 recruitingLast updated: June 17, 2026

There are 99 actively recruiting skin cancer clinical trials across 23 countries. Studies span Not Applicable, Phase 2, Phase 1, Early Phase 1, Phase 3, Phase 4. Top locations include Houston, Texas, United States, Boston, Massachusetts, United States, Nashville, Tennessee, United States. Updated daily from ClinicalTrials.gov.


Skin Cancer Trials at a Glance

99 actively recruiting trials for skin cancer are listed on ClinicalTrialsFinder across 6 cities in 23 countries. The largest study group is Not Applicable with 32 trials, with the heaviest enrollment activity in Houston, Boston, and Nashville. Lead sponsors running skin cancer studies include Alpha Tau Medical LTD., Wright State University, and Region Skane.

Browse skin cancer trials by phase

Treatments under study

About Skin Cancer Clinical Trials

Looking for clinical trials for Skin Cancer? There are currently 61 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Skin Cancer trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Skin Cancer clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 99 trials

Recruiting
Not Applicable

Alpha Radiation Emitters Device (DaRT) for the Treatment of of Malignant Cutaneous Tumors

Skin CancerCutaneous TumorCutaneous Metastasis
Alpha Tau Medical LTD.80 enrolled2 locationsNCT04068155
Recruiting
Not Applicable

Alpha Radiation Emitters Device (DaRT) for the Treatment of Cutaneous, Mucosal or Superficial Soft Tissue Neoplasia

Skin CancerMucosal Neoplasm of Oral CavitySoft Tissue Neoplasm
Alpha Tau Medical LTD.56 enrolled1 locationNCT04534127
Recruiting
Not Applicable

Alpha Radiation Emitters Device (DaRT) for the Treatment of Cutaneous SCC for Immunocompromised Patients

Skin CancerSquamous Cell CarcinomaBrachytherapy+3 more
Alpha Tau Medical LTD.28 enrolled11 locationsNCT06615635
Recruiting

Prospective Collection of Clinical Data and Human Body Material (HBM) of Cutaneous Melanoma, Non Melanoma Patients and Healthy Controls. Biobank Huidkanker

Skin Cancer MelanomaSkin Cancer, Non-Melanoma
Universitaire Ziekenhuizen KU Leuven7,500 enrolled1 locationNCT07266142
Recruiting
Not Applicable

Rural Adult and Youth Sun Protection Study

Skin CancerMelanoma (Skin)
University of Utah843 enrolled2 locationsNCT06439979
Recruiting
Early Phase 1

A Randomized Controlled Trial of Topical 5% Niacinamide for Skin Cancer Prevention in Transplant Recipients

Skin CancerCutaneous Squamous Cell Carcinoma (CSCC)Actinic Keratosis (AK)+1 more
Marissa Lobl20 enrolled2 locationsNCT07286318
Recruiting
Not Applicable

Negative Pressure Wound Therapy for Split Thickness Skin Grafting to the Lower Leg After Excision of Skin Tumour: A Multicentre Randomised Study

Skin GraftingSurgical wound infectionSkin Cancer+9 more
Region Skane242 enrolled1 locationNCT07040683
Recruiting
Not Applicable

Comparing Numbing Techniques in Mohs Micrographic Surgery

Skin Cancer FaceSkin Cancer Scalp
Abramson Cancer Center at Penn Medicine150 enrolled1 locationNCT07222241
Recruiting
Not Applicable

CARES : Customized Aftercare Report for Evaluated Skin Cancer Patients

Skin CancerManagementLow Risk
Universitaire Ziekenhuizen KU Leuven150 enrolled1 locationNCT07330323
Recruiting
Not Applicable

Mechanisms for Laser-Induced Rejuvenation

Skin Cancer
Wright State University12 enrolled1 locationNCT06489301
Recruiting
Phase 2

Cryoablation+Ipilimumab+Nivolumab in Melanoma

Metastatic MelanomaSkin Cancer
Massachusetts General Hospital37 enrolled1 locationNCT05779423
Recruiting

Liquid Biopsy Multi-Omics and Biomarker Development in Melanoma

Melanoma (Skin Cancer)
Xijing Hospital200 enrolled1 locationNCT07584291
Recruiting
Phase 1

Brodalumab in the Treatment of Immune-Related Adverse Events

Breast CancerLiver CancerEsophageal Cancer+15 more
Brian Henick, MD11 enrolled1 locationNCT06673329
Recruiting
Not Applicable

Adaptive Symptom Self-Management Immunotherapy Study

Breast CancerLung CancerColon Cancer+2 more
University of Arizona400 enrolled3 locationsNCT05715255
Recruiting
Phase 1Phase 2

Study of AMXT 1501 and DFMO in Combination With Standard Therapies in Advanced Solid Tumors

Melanoma (Skin Cancer)HER2-low Hormone Receptor Positive Breast Cancer
Aminex Therapeutics, Inc.92 enrolled12 locationsNCT07287917
Recruiting
Not Applicable

Exploratory Study With Parallel Controls on the Safety and Efficacy of Neoadjuvant Low Branched-Chain Amino Acid Diet in Combination With Anti-PD-1 Monoclonal Antibody for Stage III Melanoma

Melanoma (Skin Cancer)
Xijing Hospital80 enrolled1 locationNCT07586891
Recruiting
Early Phase 1

Efficacy and Safety of Neoadjuvant Cadonilimab Plus High-Dose Recombinant Human Interferon α1b in Stage III/IV Melanoma.

Melanoma (Skin Cancer)
Xijing Hospital10 enrolled1 locationNCT07586904
Recruiting
Not Applicable

Pilot Study of Bone Mineral Density Changes During Anti-PD-1 Immunotherapy

Non-small Cell Lung CancerMelanoma (Skin Cancer)Invasive Mammary Carcinoma+5 more
Jessica Mezzanotte Sharpe25 enrolled1 locationNCT07555210
Recruiting

Raman Spectroscopy and Skin Cancer

Skin CancerBasal Cell CarcinomaSquamous Cell Carcinoma
Tiezhi Zhang20 enrolled1 locationNCT06384924
Recruiting

Integrated Cancer Repository for Cancer Research

Breast CancerLiver CancerEsophageal Cancer+47 more
University of Nebraska999,999 enrolled42 locationsNCT02012699