RecruitingPhase 1NCT07429448

Comparison Of Clinical Outcomes of Intraperitoneal Bupivacaine Instillation Versus Placebo as Preemptive Analgesia in Patients Undergoing Open Appendectomy

Sponsor

Sardar Umer Rehman

Enrollment

60 participants

Start Date

Dec 16, 2025

Study Type

INTERVENTIONAL

Conditions

Appendectomy

Summary

To compare the clinical outcomes of intraperitoneal bupivacaine instillation vs placebo as preemptive analgesia in patients undergoing open appendectomy

Eligibility

Min Age: 20 YearsMax Age: 60 Years

Inclusion Criteria1

Patients presenting to the emergency department undergoing open appendectomy.

Exclusion Criteria8

Patients undergoing interval appendectomy or having perforated appendix as evident by examination (abdominal tenderness/ fever) and USG findings (presence of abscess, fluid collection, or free air).
Uncontrolled medical disease (DM: BSL \>200mg/dl, HTN: BP \>140/90)
History of chronic kidney or liver disease/ psychiatric illness/ Active peptic ulcer disease (as determined on history and medical records)
Alcoholics
History of chronic pain or patients on analgesic medications
Pregnant females
History of allergy to bupivacaine/ ketorolac as determined on history
Children, Adolescents and patients with mental illness.

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