RecruitingNCT07430839

Exercise and Carotid Artery Function in Metabolic Syndrome

Identifying Sex-specific Carotid Endothelial Dysfunction in Young Adults With Metabolic Syndrome

Sponsor

University of Wisconsin, Madison

Enrollment

48 participants

Start Date

Dec 1, 2025

Study Type

OBSERVATIONAL

Conditions

Metabolic Syndrome

Summary

The purpose of this study is to determine 1) if young adults with metabolic syndrome display endothelial dysfunction of the internal carotid artery in a sex-specific fashion and 2) if this endothelial dysfunction can be acutely improved with a single bout of exercise. This will be achieved by testing internal carotid artery function before and after a 30-minute bout of moderate intensity exercise. 48 young adults with and without metabolic syndrome will be enrolled and will be on study for approximately 5.5 hours over 4 study visits.

Eligibility

Min Age: 18 YearsMax Age: 40 Years

Inclusion Criteria6

Waist circumference greater than 102 cm (males) or 82 cm (females)
Triglycerides over 150 mg/dL
HDL cholesterol less than 40 mg/dL (males) or 50 mg/dL (females)
Blood pressure ≥130/85 mmHg
Fasting plasma glucose over 110 mg/dL
\- meet age criteria

Exclusion Criteria26

Current smoker, defined as more than 5 cigarettes over past 30 days
Current diagnosis or history of:
peripheral vascular disease
hepatic disease
renal disease
lung disease
gastrointestinal disorders/bleeding
hematologic disease
stroke
myocardial infarction
coronary heart disease
congestive heart failure
heart surgery
sleep apnea
autoimmune diseases
traumatic brain injury, concussion, stroke, or seizures
Asthma
Polycystic ovarian syndrome
Type II diabetes
Currently pregnant or breastfeeding
Current musculoskeletal injury Medication use known to influence cardiovascular function, other than oral contraceptives
Hormonal contraceptive use, such as intrauterine device or hormonal implant use
Participants with ICAs unsuitable for imaging, as assessed during the screening visit via doppler ultrasonography
BMI greater than 25 kg/m2
Blood pressure over 125/80 mmHg
Meeting any MetSyn criteria listed for MetSyn cohort

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Interventions

BEHAVIORALexercise

30 minute bout of cycling

DIAGNOSTIC_TESTDiagnostics

* Doppler Ultrasound used to non-invasively assess the diameter and blood flow going into an artery, the ICA in this study. * Indirect calorimeter in tandem with semi-recumbent bike used to assess O2 consumption * heart rate monitor

OTHERInhaled CO2-mixed air

Three gases of different composition are used to ensure that the proper PETCO2 administration desired for this study occurs in tandem with keeping inspired O2 content constant. This is achieved by used a 5% O2, 95% CO2 tank, a 5% O2, 95% N2 tank, and a 100% O2 tank. In tandem, the use of these three tanks allows for precise control of PETCO2 without a change in inspired O2.