Assessing the Association Between H. Pylori Persistence and the Severity of Insulin Resistance in Patients With Metabolic Syndrome
Assessing the Association Between H. Pylori Persistence and the Severity of Insulin Resistance in Patients With Metabolic Syndrome Cohort Observational Study
Center of New Medical Technologies
100 participants
Apr 1, 2026
OBSERVATIONAL
Conditions
Summary
This retrospective cohort study evaluates the association between H. pylori persistence and insulin resistance severity (HOMA-IR) in 100 patients with metabolic syndrome at Novosibirsk's Center for New Medical Technologies (CNMT). Patients are divided into infected (n=50) and non-infected (n=50) groups, assessing metabolic parameters, gastro panel, and CRP. Primary endpoint: HOMA-IR differences; secondary: correlations with gastric inflammation and metabolic markers.
Eligibility
Inclusion Criteria2
- Verified MS per NCEP-ATP III criteria.
- Ability to undergo all procedures (fasting blood draw, breath test, stool antigen, endoscopy/biopsy, anthropometry).
Exclusion Criteria9
- Current metabolic-influencing therapy.
- Acute/chronic infection or autoimmune flare.
- Interventional study participation in last 3 months.
- Planned surgery/long hospitalization.
- Active malignancies.
- Severe liver/kidney failure.
- Pregnancy/lactation.
- Gastric resection or upper GI reconstruction.
- Type 1 diabetes.
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Locations(1)
View Full Details on ClinicalTrials.gov
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NCT07501858